What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort…
Gene therapy represents a paradigm shift in modern medicine, offering potential cures for previously untreatable genetic disorders. Despite its growing clinical relevance and increasing integration into healthcare systems, knowledge of gene therapy among…
Arctosa springiosa Yin, Wang, Xie & Peng, 1993 is reported for the first time from India based on a freshly collected specimen from northeast India and specimens deposited at the National Zoological Collection of Zoological Survey of India (NZC-ZSI), Kolkata.…
Phenacoccus saccharifolii (Green) (Hemiptera: Pseudococcidae), commonly known as the sugarcane crown mealybug, has become a major pest of concern in recent years in the sugarcane growing areas of Tamil Nadu state, India. It is found either alone or in…
Leucinodes orbonalis Guenée, 1854 is a major internal feeder of solanaceous crops in the Indo-Malayan region and an economically important quarantine pest. During field surveys conducted in September 2025 in Arunachal Pradesh, India, fruit-boring larvae were…
Introduction. Rheumatoid arthritis (RA) contributes to sexual dysfunction through physical challenges such as pain, joint stiffness, and fatigue, as well as psychological effects. Patients with RA are less likely than healthy individuals to perceive themselves…
A single year field investigation was conducted at Mandya, Karnataka during August-December 2023 (Rabi) and January-April 2024 (Summer) to evaluate the seasonal population dynamics of major sucking pests of chilli and their relationship with weather…
Species abundance and foraging dynamics of pollinators associated with safflower revealed that the crop was visited by a total of 18 insect species. Among these, seven species belonged to the order Hymenoptera, followed by five species of Diptera, four species…
The pink stem borer, Sesamia inferens (Lepidoptera: Noctuidae), is a polyphagous and destructive pest of major cereal crops, causing substantial yield losses. Biology, age-stage survival and reproductive potential of S. inferens were evaluated using the…
Substrate channeling enhances efficiency and prevents toxicity by directing unstable intermediates between active sites. Trimethylamine N-oxide demethylase (TDM) degrades trimethylamine N-oxide (TMAO) to dimethylamine and formaldehyde (HCHO), but the fate of…
PURPOSE Post-operative stereotactic radiation (SRT) is the standard-of-care for resected brain metastases. Implantation of cesium-131 collagen tiles (tile-based radiation therapy, TBRT) initiates focal radiation immediately after resection, potentially…
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Autophagosome biogenesis depends on the coordinated action of proteins and lipids. However, how LC3B organizes at high density and contributes to autophagy-associated functions remains unclear. Using molecular dynamics simulations and super-resolution…
As infectious causes of child mortality decline, birth defects represent a growing relative proportion of neonatal and under-five deaths (as well as unmeasured morbidity) in low- and middle-income countries (LMICs), underscoring the need to integrate their…
Accurate continuous glucose monitoring (CGM) in non-invasive way have remained highly challenging, where current universal approach of “one-sensor-fits all” have been always frustrated, since the correlations between non-invasive parameters and blood glucose…
Genomic imprinting is a classic epigenetic phenomenon first discovered in maize, which occurs predominantly in the triploid endosperm and is thought to mediate parental influences on seed development. Previous studies based on bulk RNA sequencing of manually…
Forensic microbiology leverages postmortem microbiome succession as a promising biomarker for estimating the postmortem interval (PMI). However, current methods are constrained by sparse sampling (typically 3–5 time points) and limited cross-anatomical…
Abstract Bacterial pathogens have adapted secreted effector proteins that hijack host ubiquitination to gain control over host responses. These effectors can exhibit, for example, E3 ligase or deubiquitinase activities, often without any homology to eukaryotic…
Abstract G protein-coupled receptors (GPCRs) govern diverse cellular responses and are crucial drug targets. However, the sequence of structural events from G protein recognition to GDP release has remained elusive. Here, we leveraged the viral chemokine GPCR…
Reduced antibiotic target activity is a major driver of antibiotic treatment failure. While this has mostly been linked to the presence of low-energy bacteria, a recent study by Taher and colleagues suggests that reduced building-block synthesis can also…
Secretory and membrane protein biogenesis occurs at ribosome-bound translocons in the endoplasmic reticulum (ER) membrane. Translocons consist of the Sec61 protein-conducting channel and various maturation factors including chaperones, modification enzymes and…
Abstract Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity. However, its potency is often limited by innate immune…
We investigated the role of tumor microenvironment (TME) in evolution of liver cirrhosis to hepatocellular carcinoma (HCC). Nonmalignant hepatic tissues, including chronic hepatitis and cirrhosis, retained expression of liver specific miR-122 and hepatocyte…
Neuronal loss is a hallmark of neurodegenerative diseases. Phosphatidylserine (PS), a key “eat me” signal, is exposed on stressed viable neurons, triggering their premature phagocytosis by activated glia. We investigated whether PS masking could serve as a…
Editor in Chief of JAMA+ AI Roy Perlis, MD, MSc, and Rochelle P. Walensky, MD, MPH, professor of medicine at Harvard Medical School, discuss the role of women physicians in shaping AI’s impact on health care in this episode of the JAMA+ AI Conversations…
ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered by…
Tau, a neuronal microtubule-associated protein (MAP), organizes the axonal cytoskeleton, and regulates intracellular transport. Tau hyperphosphorylation is linked to neurodegeneration in tauopathies, including Alzheimer’s disease. Tau binds microtubules…
Abstract Nucleocytoplasmic transport occurs via nuclear pore complexes (NPCs), ~40-60 nm wide pores lined with intrinsically disordered proteins that are rich in Phe-Gly motifs (FG-Nups) that form a selective barrier. Molecules larger than ~50 kDa are…
Abstract Cell and organismal growth is controlled not only by the availability of nutrients, but also the ability to dynamically sense and respond to changes in metabolic demand. We have identified a protein, TMEM263 (also known as C12orf23) as a mechanistic…
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bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
Long-term cognitive outcomes following COVID-19 remain poorly characterized in South Asian populations. We assessed 181 Indian adults---99 with a reported history of COVID-19 at least six months earlier and 82 healthy controls---using standardized tests of…
Background Oral glucose tolerance test (OGTT), the gold standard for diagnosing gestational diabetes mellitus (GDM), faces significant implementation challenges, prompting interest in alternative biomarkers, such as glycated hemoglobin (HbA1c), for early…
Routine facility-based testing for hepatitis C virus (HCV) remains underutilised in India despite national screening policy. WHO has recommended HCV self-testing (HCVST) since 2021 to increase access to testing services. This study evaluated the HCVST by…
Background: Determining the cause of death in electrocution is often challenging at autopsy, particularly when characteristic external electrical marks are absent. Reliable internal markers are scarce, and the neuropathological changes associated with…
Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not…
Objective. To identify antimicrobial stewardship targets by triangulating provider knowledge and practice, government-facility prescribing indicators and patient-reported treatment experience in three districts of Chhattisgarh, India. Methods. We analysed…
The transcriptome-wide association study (TWAS) is a powerful approach to identifying novel genes associated with complex phenotypes. Standard TWAS approaches build a prediction model for the genetic component of expression based on reference transcriptome…
Characterizing the enzymatic accommodation of circular agricultural fertilizers is critical for informing strategies to remediate widespread soil sulfur hunger. Here, we present an exploratory in-silico investigation evaluating the active-site cleft of sulfate…
Biomarker discovery from high-dimensional RNA sequencing data remains challenging. Conventional methods such as differential expression analysis, pairwise protein-protein interaction networks, and weighted gene co-expression network analysis suffer from…
Elucidating how microbes associate with their hosts and respond to different environments is fundamental to our understanding of symbiosis. Here, we investigate the molecular and genetic mechanisms enabling the honey bee symbiont Bombella apis to colonize and…
STUDY QUESTION Is genetic liability to endometriosis associated with iron homeostasis, and is this relationship potentially causal? SUMMARY ANSWER Genetic evidence indicates that reduced systemic iron status is associated with increased risk of endometriosis,…
Background. Benzodiazepine withdrawal can be prolonged and disabling, with symptoms extending beyond anxiety and insomnia. We characterized symptom burden and functional impairment in a specialty taper cohort and evaluated an exploratory rule for organizing…
Objective: To examine what a dementia-associated electroencephalography (EEG) entropy difference permits us to infer about brain dynamics by testing its dependence on permutation-entropy (PE) representation. Methods: Four PE settings represented identical…
INTRODUCTION: Early detection of Alzheimer's disease (AD) remains challenging. EEG offers a scalable, non-invasive tool for patient stratification, but its relationship to ATN-defined staging is poorly understood. METHODS: EEG was recorded in 60 participants…
Background: Erythritol and xylitol, naturally present in fruits and vegetables, are widely used as alternative sweeteners with minimal glycemic and insulinemic effects. Both are also produced endogenously, with elevated plasma concentrations reported in…
The COVID-19 pandemic substantially disrupted tuberculosis (TB) prevention, diagnosis, and treatment services worldwide. Despite increased TB notifications in Nepal during the post-pandemic recovery period, the geographic distribution and temporal clustering…
Background Schistosomiasis is a parasitic disease caused by flatworms known as schistosomes. The infection cycle starts when people shed eggs through the stool or the urine. Larva infects freshwater snails to later infect humans through the skin during water…
Frailty assessment is important while awaiting lung transplantation (LTx), as frailty is associated with disability and death before and after LTx. We assessed known risk factors and/or frailty indicators in frail, pre-frail, and non-frail patients according…
Study Question. COPD exacerbations with respiratory failure have an outsized impact on morbidity, mortality, and healthcare costs. Physicians treat these severe events with high doses of corticosteroids out of concern for intrinsic corticosteroid resistance.…
Introduction Low back pain (LBP) is a common leading cause of functional disability in adults worldwide, presenting with Modic changes that are visible within the endplates of the vertebral body under magnetic resonance imaging (MRI). Modic changes (MC) are…
BACKGROUND: Existing models for discharge to long-term institutional care after stroke are developed within single health systems and pool to an area under the curve near 0.80, but none is accompanied by an estimate of how much of the outcome is a property of…
Brucellosis is a globally distributed and widely under-appreciated zoonotic bacterial disease that causes infertility and abortion in livestock and febrile illness in humans, sometimes with debilitating sequelae. Brucellosis incidence estimates typically focus…
Background and Objectives: More research is required to determine the associations of high-density lipoprotein (HDL) cholesterol concentration and particle count with mortality. The objectives of this analysis were to investigate whether there were non-linear…
Introduction Vaccination against human papillomavirus (HPV) is the most effective strategy for preventing cervical cancer. We evaluated HPV Vaccine Integrated Service Implementation (HPV-VISION), a program aimed at integrating HPV vaccination with adolescent…
Frontotemporal lobar degeneration (FTLD) encompasses clinically and biologically heterogeneous syndromes that are unlikely to be captured by a single blood biomarker. Although plasma neurofilament light (NfL) chain reflects neuroaxonal injury, multiplex…
Background: Cervical cancer (CC), mostly associated with high-risk human papillomaviruses (hrHPV) infection, is the most common cancer that disproportionately affects women in developing countries, including Ethiopia. Early detection of CC and initiation of…
We report a neonate with IOPD who had high pre-existing anti-AAV9 antibody titers, which precluded eligibility for AAV9-mediated gene therapy (GC301). Preconditioning with a single dose of the IgG-degrading enzyme GC801 (0.2 mg/kg) safely reduced serum IgG…
Apolipoprotein E (APOE) genotype is theorised to influence dementia risk partly through effects on blood-brain barrier (BBB) function, but clinical studies examining APOE effects on BBB biomarkers report inconsistent results. Therefore, this systematic review…
The role of peripheral immunity in Parkinson's disease (PD) remains incompletely understood. Here, we performed paired single-cell RNA sequencing (scRNA-seq) and T-cell receptor (TCR) profiling of 630k peripheral blood mononuclear cells (PBMCs) from 168 donors…
Structural variants (SVs), including variable number tandem repeats (VNTRs), are a major source of human genetic variation, but their impact on the proteome remains poorly characterized. Using a long-read assembly-based reference panel, we imputed 54,578…
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Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
Prospective, multicenter, randomized, double-blind, parallel group, placebo- controlled, efficacy and safety phase 3 study of an intravenous human plasma- derived C1 esterase inhibitor (C1-INH) concentrate in participants with congenital…
The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia…
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Miricorilant in Adult Patients with Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH)
This is a Phase 3 global, multicenter, 52-week, open-label extension (OLE) rollover study for subjects completing study CN012-0026, CN012-0027 or CN012-0056. Subjects (randomized or non-randomized) who complete the 38-week CN012-0026 study,…
The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival…
The purpose of the study is to assess the efficacy and safety of darolutamide in combination with standard androgen deprivation therapy (ADT) in patients with metastatic hormone sensitive prostate cancer.
This is a phase 3, single arm, open-label study evaluating the effectiveness of TOL2506 to suppress ovarian function in premenopausal women with HR+, HER2-negative breast cancer. The study will also aim to assess the safety of TOL2506 in…
In this study, researchers will learn more about the use of felzartamab in participants with primary membranous nephropathy, also known as PMN. In people with PMN, autoantibodies build up in the glomeruli of the kidney. Antibodies are…
This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal…
This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions…
This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke). This study is for people who had an acute stroke or woke up with a stroke and were last seen well more than…
This study is open to adults with certain kidney conditions, including secondary focal segmental glomerulosclerosis (sFSGS), treatment-resistant primary minimal change disease (TR-pMCD), Alport Syndrome (AS), and treatment-resistant primary…
The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.
The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in…
The purpose of this study is to evaluate efficacy, safety and tolerability of s.c. ianalumab administered in participants with diffuse cutaneous systemic sclerosis relative to placebo
The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss…
Primary Objective: \- To confirm appropriate dose levels of fitusiran when administered to male pediatric participants (ages 1 to \<12 years of age) with severe hemophilia A or B Secondary Objectives: * To characterize the safety and…
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
The purpose of this study is to demonstrate the efficacy and safety of ianalumab (VAY736) 300 mg administered subcutaneously (s.c.) monthly for 52 weeks in adult participants with Sjögren's disease who have high symptom burden.
The purpose of this study is to measure the efficacy and safety of rilvegostomig with gemcitabine plus cisplatin vs. durvalumab with gemcitabine plus cisplatin as first line treatment for patients with advanced BTC.
This randomized phase II/III trial studies how well cediranib maleate and olaparib work when given together or separately, and compares them to standard chemotherapy in treating patients with ovarian, fallopian tube, or primary peritoneal…
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a curative option for patients with acute myeloid leukemia (AML). However, transplantation related toxicity and mortality as well as the existence of HLA identical sibling…
The purpose of the present Phase 3 trial is to confirm the efficacy and safety of glepaglutide 10 mg twice weekly in a patient population with SBS-IF and generate additional long-term safety data. Glepaglutide is the International…
The objective of the study is to assess safety of panitumumab-IRDye800 in pediatric patients undergoing brain surgery to remove suspected tumors.
This study aims to evaluate a new pre-surgery (neoadjuvant) treatment for patients with stage II-III non-small cell lung cancer (NSCLC). Currently, standard pre-surgery treatment involves immunotherapy combined with chemotherapy. While…
The aim of this trial is to demonstrate similarity in efficacy between ABP 938 8 mg and aflibercept (US) 8 mg by evaluating the change in best corrected visual acuity (BCVA) in participants with neovascular age-related macular degeneration…
The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for…
Brain tumor treatment is hampered by the blood-brain barrier (BBB). This barrier prevents drugs carried in the bloodstream from getting into the brain. If the BBB can be opened, making it temporarily more permeable, drugs may able to better…
This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that has spread from where it first started (primary site) to other places in the…
The purpose of this study is to find out what treatment works best for participants with metastatic prostate cancer that are not responding to hormone treatment and docetaxel and are also Prostate-specific membrane antigen(PSMA) positive.
Increased pyruvate-to-lactate conversion is a hallmark of HCC metabolism. In parallel, activation of pro-inflammatory immune cells triggers a metabolic switch towards anaerobic glycolysis. Hyperpolarized carbon-13 (13C) pyruvate MRI is a…
This study is evaluating the activity and efficacy of Stereotactic Ablative Body Radiotherapy (SABR) for the treatment of kidney cancers.
This study aims to provide real-world information about the duration, safety, and overall benefit of DaxibotulinumtoxinA (also called DAXI) treatment for adults living with blepharospasm (BSP), a condition that causes uncontrolled blinking…
This is a Phase 2 single arm study to evaluate efficacy and safety of Pembrolizumab before with BEAM ASCT followed by Pembrolizumab maintenance for 1 year. Patients will receive 200 mg Pembrolizumab Q3week starting at day - 28 before stem…
This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.
This study evaluates and compares the analgesic efficacy and safety of adding dexamethasone versus dexmedetomidine to bupivacaine in an ultrasound-guided pericapsular nerve group (PENG) block combined with a lateral femoral cutaneous nerve…
This clinical trial is being done to evaluate the safety and clinical response of late surfactant treatment with budesonide in extremely preterm infants requiring mechanical ventilation at 7-14 days of age.
In this study, 18F-Florastamin PET/CT will be performed in patients with at least intermediate risk prostate cancer, to assess the diagnostic performance and safety of 18F-Florastamin PET/CT imaging. This study will first carry out the…
This study is researching an experimental drug called dupilumab (called "study drug"). The study is focused on children with active eosinophilic esophagitis (EoE; an inflammatory disease of the esophagus) which impacts feeding and…
This is a multi-part Phase 2 study to evaluate the efficacy and safety of azenosertib (ZN-c3) in subjects with Platinum-Resistant, High-Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. Part 2 of the study will be…
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Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
Linux is a specialty-focused domestic formulations platform with a portfolio of over 125 brands spanning ~400 SKUs. The post Linux secures USD 70mn strategic investment from ChrysCapital and Tata Capital Healthcare Fund…
A consortium of General Atlantic and Renova Hospitals is nearing a deal to acquire Siemens Healthineers’ Indian cancer-care network, potentially valuing American Oncology Institute at ₹1,200-1,500 crore.
Governor Greg Abbott announced the first round of Rural Texas Strong grant awards, providing $51 million in federal funding through the Texas Health and Human Services Commission (HHSC) to eligible rural hospital…
The country's largest drugmaker by market capitalisation closed a syndication of a near-$12 billion, 18-month bridge loan earlier this year for Organon's acquisition. The syndication also included State Bank of India,…
The agreement is expected to add South Africa to Elitecon’s international network and create additional employment at its Nashik plant.
Afghanistan’s Public Health Minister Mawlawi Noor Jalal Jalali met with Yatin Patel, India’s chargé d’affaires in Kabul, and the two sides discussed strengthening health services and expanding cooperation between the two…
The Pharma Park spread across 141 acres, is being built with plug-and-play facilities for pharmaceutical manufacturing, common utilities and logistics support. The post Chhattisgarh CM announces 141-acre Pharma Park in…
Jeevan Kasara, Chairman of the Board, STERIS Healthcare, believes India’s next pharma growth story will be built on trust, innovation and value, not cost alone. He discusses the China+1 opportunity, the shift towards…
India’s medical device market is expanding well beyond high-value equipment such as imaging systems, robotic surgery platforms, and advanced diagnostic machines. Fortune Business Insights estimates the overall market at…
Kerala is expected to get an All India Institute of Medical Sciences (AIIMS) in the near future, Vice President CP Radhakrishnan has said. He also stressed that advances in artificial intelligence, robotics and digital…
The research team at the BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram, has developed a new nanopore-based sensing technology that could help detect biomarkers linked to Parkinson’s disease…
Chief Minister Thakur Sukhvinder Singh Sukhu inaugurated an MRI machine worth Rs. 23 crore and a Tertiary Care Cancer Centre equipped with LINAC and CT Simulator machines, costing Rs. 2.29 crore, at Shri Lal Bahadur…
The Kerala government has constituted a technical expert committee to prepare a detailed project report (DPR) for the proposed Oommen Chandy Health Insurance Scheme, which aims to provide insurance cover of up to Rs 25…
The Delhi High Court on Monday issued notice to the Secretary, Ministry of Health and Family Welfare, Government of India, on a contempt petition alleging non-compliance with an earlier Division Bench order concerning…
Malaysian healthcare giant IHH Healthcare on Tuesday reiterated that it will proceed with plans to increase its stake in hospital chain Fortis Healthcare to 51 per cent over the next three to five years, taking its total…
AIIMS has received approval for a new critical care and infectious diseases block and a multi-level parking facility in New Delhi, after the Delhi Urban Art Commission cleared a revised building plan submitted by the…
The Delhi High Court has annulled an order from FSSAI regarding Red Bull India's product labeling. Justice Amit Mahajan ruled in favor of the company on the grounds of natural justice. The court has allowed FSSAI to…
IHH Healthcare aims to raise its stake in Fortis Healthcare to 51 percent within three to five years. The company intends to increase Fortis' total capacity to around 10,000 beds by 2031. This decision follows a Supreme…
A bench of Justices Vikram Nath and Sandeep Mehta asked the Centre to look into the issue of hospitals mandating the purchase of medicines from their chemists and said it is the common man who suffers from this system.
Shivraj Singh Chouhan announces procurement of oilseeds and pulses by government agencies if growers sell below minimum support price
Pointing to this cost pressure, the Centre has asked states to prevent over-application of nutrients
The patent covers compounds that inhibit Vacuolar ATPase (V-ATPase), a cellular mechanism some viruses use during infection, and their use in medicaments for treating viral infections
First-time-in-India approval strengthens Akums’ presence in the growing cardiovascular therapeutics segment The post Akums receives DCGI approval for Colchicine 0.5 mg tablets appeared first on Express Pharma .
The Supreme Court clarified the forensic audit's focus is on Fortis Healthcare Holdings Private Limited and the Singh Brothers. This audit is not a broad inquiry into the dealings of other banks. The court highlighted…
The collaboration aims to strengthen industry-academia collaboration to drive translational research and innovation The post OPPI collaborates with NIPER Hajipur to advance research excellence appeared first on Express…
ai3Bio has emerged from stealth with $48 million in funding and a buzzing platform for targeting T cells in autoimmune disease.
Novo’s ongoing efforts to rejuvenate its pipeline have seen the Big Pharma turn to one of the most in-demand drug developers in China.
AstraZeneca is investing $2 billion in Summit Therapeutics to accelerate the development of PD-1xVEGF bispecific ivonescimab in combination with antibody-drug conjugates (ADCs). The newly minted partners will start by…
Precision Neurosciences, which specializes in brain-computer interface technology, raised $250 million in an oversubscribed Series D financing round.<br>
Sofinnova Partners has hauled in 82 million euro ($93.3 million) in an oversubscribed financing round. The European venture capital group said it will use the cash to expand its medtech creation strategy in Europe and…
Merck & Co. has become the latest pharma to jump on the KRAS G12D bandwagon, paying $400 million to China’s SciBrunch for a preclinical candidate.
Daiichi Sankyo and Merck & Co. have withdrawn an antibody-drug conjugate (ADC) filing after the FDA said they lacked the data for accelerated approval in a lung cancer population.
Novo has struck a 1.17 billion euro ($1.3 billion) deal to combine Nanexa’s long-acting injectable drug delivery platform with its obesity and Type 2 diabetes drugs.
Roche’s Genentech is paying Earendil Labs $55 million upfront to discover and develop multiple bispecific antibodies. The deal, which focuses on oncology, includes milestones that could take the deal's value above $1.5…
ADARx Pharmaceuticals has overshot its own IPO ambitions, as fellow RNA-focused biotech City Therapeutics also plans a public listing.
AstraZeneca is teaming up with Summit Therapeutics to test its PD-1/VEGF bispecific ivonescimab alongside AstraZeneca’s antibody-drug conjugates.
Novo forges this deal as the company looks to extend the lead secured from its first-to-market advantage in the oral weight loss drug arena.
AstraZeneca has agreed to invest $2bn in newly issued equity in Summit Therapeutics to develop combination therapies using the bispecific antibody ivonescimab and ADCs across multiple tumour types.
Tolerance Bio has signed an agreement securing an exclusive licence from Tanabe Pharma for TLB-33 in a deal of up to around $560m.
A newly launched $5 million clinical trial program allows clinical trial sponsors to start trials in as little as 45 days in Ontario.
As antiviral specialist Enanta Pharmaceuticals endeavors to expand into immunology, the company has decided to lay off 37 employees, Fierce has learned.
As always, if you know of layoffs occurring at a biotech, please reach out to the Fierce Biotech editorial team.
uniQure’s Huntington’s disease gene therapy has failed to significantly slow disease progression after 48 months, sending the biotech’s stock down 41% when trading began. But mitigating circumstances and the ongoing…
Roche has slammed the brakes on an obesity antibody after the candidate showed little hope of hitting its endpoints in a phase 2 study.
A phase 3 trial of Mirum Pharmaceuticals’ chronic hepatitis delta virus drug candidate has hit its primary endpoint, furthering the biotech’s efforts to enter a space recently colonized by Gilead Sciences.
The Biomedical Advanced Research and Development Authority (BARDA) has awarded Scynexis a $214 million contract for the development of a treatment for invasive fungal infections.
After vaulting into the clinic by licensing a fusion protein last month, Tolerance Bio has continued to strengthen its thymus-focused pipeline by picking up an anti-IL-33 drug from Tanabe Pharma.
Two of Kodiak Sciences’ drug candidates have matched aflibercept in a phase 3 clinical trial, positioning the biotech to seek FDA approval of one of the eye disease assets this year.<br>
NAMs could transform drug safety testing—but proving repeatability and cell health remains the key hurdle to widespread adoption.
As the race to harness CAR-T cells for autoimmune diseases hits a rough patch, a Bay Area biotech is gliding over the potholes with an early sign of efficacy in lupus.
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