What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort…
Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We…
Background Acute motor and sensory axonal neuropathy is a rare, severe variant of Guillain-Barré syndrome marked by rapid progression, autonomic dysfunction, and delayed recovery. The patient in this report was treated in a resource-limited intensive care unit…
BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced…
Background: Widely accessible education on organ donation and transplantation (ODT) is a tool to reduce waiting lists, as <10% of transplant needs are met (Global Observatory on Donation and Transplantation). We aimed to assess the current state of access to…
This study examined the abductor pollicis longus (APL) and abductor pollicis brevis (APB) muscles, which are key muscles involved in thumb abduction and fine motor function, with anatomical variations of the APL particularly accessory tendons implicated in the…
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia causes substantial morbidity, but tissue reservoirs that permit bacterial persistence remain poorly defined. Using intravenous USA300 MRSA infection in mice, multiplexed imaging, dual-species…
Gliomas are diffusely infiltrative, requiring accurate and sensitive diagnostic tools during surgical resection. Mutations in isocitrate dehydrogenase enzyme (IDH) alter its normal activity and result in accumulation of a unique oncometabolite,…
BACKGROUND: Sagittal imbalance often causes pain and disability in patients with degenerative spondylolisthesis (DS). This occurs due to the slipping of one vertebra over another as a result of degenerative changes in the disc and facet joints. In this study,…
Background: Thyroglossal duct cyst (TGDC) is the most common congenital anterior neck mass, typically presenting in the paediatric age group as a painless midline swelling. The diagnosis is primarily clinical, supported by imaging modalities and fine needle…
Gene therapy represents a paradigm shift in modern medicine, offering potential cures for previously untreatable genetic disorders. Despite its growing clinical relevance and increasing integration into healthcare systems, knowledge of gene therapy among…
ABSTRACT Introduction: The classical lateromedial “bull’s eye” technique for fluoroscopy-guided access for percutaneous nephrolithotomy (PCNL) may be inappropriate for a superior calyx puncture since its infundibulum has a craniocaudal (CC) orientation. We…
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Abstract Background G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read…
Biomolecular networks underlie both natural biological processes and engineered cellular technologies, from intracellular regulation and ecological dynamics to biomanufacturing, smart therapeutics, and cell-based diagnostics. However, designing chemical…
Abstract Alternative polyadenylation (APA) has a central role in regulation of the fate of mRNA and exhibits high variability in the brain and in neurons. However, brain APA regulation has not been mapped at cell type resolution, and the genetic control of APA…
The inability to perform forward genetics has been a major barrier to human papillomavirus (HPV) research. Here, we report a platform for phenotypic selection of HPV mutants. Our method relies on large “concordant” virus libraries, where each mutant virus…
Abstract The development of a vaccine capable of conferring sterile protection against Plasmodium , the causative agent of malaria, is a major priority for global eradication efforts. Whole-organism vaccines using liver-infective sporozoites provide high…
Abstract Mutations in the PRPF31 gene cause retinitis pigmentosa type 11 (RP11), a progressive blinding disease triggered by defects in the spliceosome, the cellular machinery responsible for RNA processing. Although gene replacement holds therapeutic promise,…
Phenylpropanoid metabolism is a crucial secondary metabolic pathway in plants. Numerous neofunctionalized and specialized enzymes emerged during plant terrestrialization, yielding metabolites contributing to environmental adaptation. Here, a cinnamyl alcohol…
Finding therapeutic antibodies that bind multiple related targets with high affinity and favorable biophysical properties remains challenging and resource-intensive. For snakebite antivenoms, this challenge is critical as treatments must neutralize toxins…
Abstract Previous adversity increases sensitivity to subsequent stressful events 1–8 , but the causal underlying changes in brain circuitry are poorly understood. Here we harnessed unbiased whole-brain activity mapping to identify circuits that are…
Abstract Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways 1,2 . Asgard archaea, which are considered the closest known prokaryotic relatives of…
T cells can respond to even a single molecular binding event of antigen to a TCR. A key step in the TCR signaling pathway that definitively exhibits this single-molecule response is the initiation of calcium influx by activation of PLCγ1 in the LAT protein…
Lipid homeostasis is orchestrated by rapid exchange and remodeling across the endoplasmic reticulum (ER), lipid droplets (LDs), and mitochondria. However, live-cell visualization of this triorganelle network remains limited by subdiffraction structures,…
Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limited. Here, we identify targeted degradation of the selenium uptake receptor lipoprotein receptor-related protein 8…
Recent studies have described an ability of cancer cells to survive engagement of apoptotic pathways following chemical and therapeutic insults, challenging the prevailing model that caspase activation inevitably leads to cellular demise. Gasdermin E (GSDME),…
Callahan and Mankin argue that extreme heat, measured by maximum 5-day average temperature, has a precise and economically meaningful effect on subnational gross domestic product per-capita growth. We reexamine this claim and find that the reported precision…
Autophagic degradation of parts of the nucleus (nucleophagy) and endoplasmic reticulum (ER-phagy) utilizes the selective autophagy receptors, Atg39 and Atg40, that link their target structures to the autophagy machinery. Here, we show that a complex of three…
Abstract Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding 1 . Distinct conformations of amyloid filaments may provide the physical…
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bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
Long-term cognitive outcomes following COVID-19 remain poorly characterized in South Asian populations. We assessed 181 Indian adults---99 with a reported history of COVID-19 at least six months earlier and 82 healthy controls---using standardized tests of…
Background Oral glucose tolerance test (OGTT), the gold standard for diagnosing gestational diabetes mellitus (GDM), faces significant implementation challenges, prompting interest in alternative biomarkers, such as glycated hemoglobin (HbA1c), for early…
Endosomal dysfunction is a presymptomatic hallmark of neurodegeneration. Recent evidence highlights dysregulation of endosomal pH as a central pathogenic hub in Alzheimer's disease (AD); however, the mechanisms linking pH shifts to neurodegeneration remain…
Cell division is fundamental to multicellular organisms, and stochastic partitioning of cellular components can strongly affect genome-wide gene expression. However, how cell division-associated stochasticity shapes cellular dynamics is poorly understood.…
Routine facility-based testing for hepatitis C virus (HCV) remains underutilised in India despite national screening policy. WHO has recommended HCV self-testing (HCVST) since 2021 to increase access to testing services. This study evaluated the HCVST by…
BackgroundDetermining the cause of death in electrocution is often challenging at autopsy, particularly when characteristic external electrical marks are absent. Reliable internal markers are scarce, and the neuropathological changes associated with…
Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not…
Neurotropic RNA viruses are major causes of fatal encephalitis worldwide, yet how infected neurons transition from antiviral defense to inflammatory cell death is not well characterized. Chandipura virus (CHPV), an emerging neurotropic rhabdovirus, causes…
It is important to determine whether native state dynamics drive the misfolding and oligomerization of the prion protein, which are important events in prion disease, and how they are modulated by conformational conversion. Native (N) mouse prion protein…
Triply periodic minimal surface (TPMS) architectures - Gyroid, Diamond, and Primitive - are increasingly used as delivery matrices for therapeutic agents. Although point-tracer diffusion and geodesic tortuosity (tau) describe solvent transport through their…
Objectives: To investigate whether standardising electronic healthcare record (EHR) data to the Observational Medical Outcomes Partnership (OMOP) common data model improves cross-dataset interoperability and enables transfer learning of clinical language…
Background: Guanica, Puerto Rico, has one of the highest concentrations of environmental polychlorinated biphenyls (PCBs). This PCB contamination coupled with persistent poverty, population loss, and repeated environmental disasters has taken a heavier toll on…
Background: Cardiovascular magnetic resonance (CMR) provides accurate, reproducible quantification of cardiac chamber size and function. Population-specific reference ranges, standardized categories for grading degree of deviation, and evidence for their…
Advances in transcriptomics have transformed our understanding of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease, revealing disrupted gene expression profiles and highlighting the multi-system biology of ALS. Despite major…
Cardiac and adiposity imaging-derived phenotypes (IDPs) provide quantitative measures of organ structure, function, and body composition and may reveal disease-relevant genetic variation not readily captured by heterogeneous clinical endpoints. Here, we…
Background Cardiovascular prevention is organized around target metrics. Blood pressure, LDL cholesterol, and A1c define treatment targets, quality metrics, and, implicitly, who is considered safe. Yet a value below a cutoff is a correlative measurement, not…
Coal-fired power plants remain a major source of fine particulate matter (PM2.5) exposure and mortality in the United States. Announced retirement dates mark when those burdens are expected to end, but rising electricity demand, partly from data centers…
Recent lifespan frameworks of aging theorize that pubertal development and cellular aging are governed by overlapping pathways, but the time lag between adolescence and older adulthood complicates the study of shared molecular mechanisms. Here we compare a…
Background: Endometriosis is a chronic gynecologic condition which has been linked with higher cardiovascular disease (CVD) risk. Although systemic inflammation is central to endometriosis and CVD pathophysiology, it remains unclear whether endometriosis is…
Background: Chronic obstructive pulmonary disease (COPD) is a progressive condition with high symptom burden. Advanced COPD management should relieve symptoms, optimise daily functioning and reduce carer burden, yet there is limited enactment of…
Background and Objective: For their acceptance as endpoints in clinical trials, biomarkers and clinical outcome assessment (COA) measures should show reliability by being reproducible (precise) and responsive to change. We evaluated precision and…
Background Temperature instability during neonatal transport contributes to adverse outcomes in preterm and low birth weight infants. Hypothermia in this population is associated with increased risk of intraventricular haemorrhage (IVH), sepsis, and death.…
Abstract Background: The 52-item Ontario Child Health Study Emotional Behavioural Scales (OCHS-EBS) has demonstrated reliability and validity evidence in Canadian population-based samples. This study evaluated an adapted item set of the Ontario Child Health…
Background: Diabetes poses a major global health and economic burden, and effective self management is essential for preventing complications. The National Health Service in England has recently announced plans to shift from analogue to digital services in…
Introduction: Tobacco use during pregnancy increases risks for adverse birth outcomes. In the US, tobacco use during pregnancy is associated with several poverty-related social determinants of health (fewer years of education, housing and food insecurity,…
Background. Safely managed drinking-water monitoring under Sustainable Development Goal target 6.1 uses source-water quality, yet Escherichia coli is common in household drinking water in Bangladesh despite near-universal improved sources. We compared source…
Background Studies of the 2018 United Network for Organ Sharing (UNOS) policy revision suggest improved early transplantation access for the sickest patients. It remains unknown whether these benefits vary as a function of time on the waitlist. Thus, we…
Severe cognitive decline due to dementia is an important clinical indicator signaling neurodegeneration. Predicting cognitive decline rates can be useful in establishing prognosis and modifying treatment regimens. The rate of decline is highly variable across…
Background and objectives: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease. Though neuropsychiatric symptoms (NPS) of CADASIL profoundly impact…
BACKGROUND Twin pregnancies have a two- to three-fold higher risk of preeclampsia (PE), but early prediction remains poor because current biomarkers and prediction models are largely derived from singleton pregnancies. Defining the biological changes that…
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Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
The purpose of this study is to evaluate long-term safety and tolerability of ianalumab in participants with systemic lupus erythematosus who have previously completed the treatment period in one of the two SIRIUS-SLE core studies…
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the…
A prospective, randomized, open-label comparative study evaluating oral itraconazole and oral posaconazole in treatment-naïve patients with CPA, with treatment for 12 months is proposed. The study will compare clinical effectiveness and…
This study aims to evaluate the efficacy and safety of crovalimab in pediatric participants with aHUS.
Patients with depression are acutely distressed, often suicidal, and unable to meet the demands of everyday life. If proven effective in a rigorously conducted multicenter randomized controlled trial (RCT), oral ketamine would provide an…
Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-2)
The overall purpose of this two-part study is to evaluate the efficacy, safety and tolerability of iptacopan (LNP023) in addition to standard of care treatment.
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with Homologous…
This study is open to adults with systemic lupus erythematosus (SLE). The purpose of this study is to find out whether a medicine called BI 3000202 helps people with SLE. The study tests different doses of BI 3000202 and aims to find the…
A multicenter, open-label Phase 2b study of selinexor (KPT-330) in participants with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who have no therapeutic options of demonstrated clinical benefit.
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find…
The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia…
The main aim of this study is to find out how well elritercept works to improve anemia in participants with myelofibrosis (MF) who are taking ruxolitinib when compared to placebo. Other aims are to learn how elritercept improves anemia…
The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival…
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they…
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme…
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will…
This study is open to adults who are at least 18 years old living with obesity and have: * a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and * moderate or advanced liver…
Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-1)
The aim of this study is to collect efficacy and safety data to support the registration of tafenoquine in India.
Background: Myelodysplastic syndrome (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN) are blood disorders that can cause serious complications in children and adults. MDS and MDS/MPN can also progress to acute myeloid…
The goal of this clinical trial is to learn if drug hydrolyzed lignin works to treat H pylori infection in adults. It will also learn about the safety of drug lignin n the sitting of H pylori infection, and if it halts the side effects…
This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a…
This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide in patients…
The goal of this clinical trial is to test the effectiveness of the study drug, ORC-13361, in preventing hearing loss in patients with NTM infection who are undergoing treatment with IV amikacin therapy. The main question this study aims to…
This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may…
This phase II trial test tests how well repurposing atovaquone works in treating patients with platinum-resistant ovarian cancer. Atovaquone is used for the treatment or prevention of certain infections. Atovaquone is in a class of…
A Phase 2 Study to Evaluate the Safety, Pharmacodynamics, Pharmacokinetics, and Clinical Activity of ADX-097 Administered Subcutaneously in Male and Female Participants Aged 16 Years or Older with Immunoglobulin A Nephropathy (IgAN), Lupus…
This randomized phase III trial studies how well pembrolizumab works compared with the current standard of care, physician/patient choice of either high-dose recombinant interferon alfa-2B or ipilimumab, in treating patients with stage…
The participants of this study will have confirmed Primary Biliary Cholangitis (PBC) and cirrhosis (scarring of the liver). PBC is a slowly progressive disease, characterised by damage to the bile ducts in the liver, leading to a build-up…
The Children Liver Disease Research and Education Network (ChiLDREN) is conducting a clinical trial to determine the feasibility, acceptability, tolerability and safety profile of IVIG treatment administered to infants after hepatic…
This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal…
This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo \[TM\]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink…
This phase III trial compares the effect of adding cetuximab to pembrolizumab versus pembrolizumab alone in treating patients with head and neck squamous cell carcinoma (HNSCC) that has come back after a period of improvement (recurrent)…
Jansen s Metaphyseal Chondrodysplasia (JMC) is a very rare disorder with only approximately 30 people known to have the disease worldwide. It is caused by parathyroid hormone 1 receptor (PTH1R) variants leading to constitutive activation of…
Background: Biochemically recurrent prostate cancer (BCR) occurs when prostate-specific antigen (PSA) levels in the blood rise after surgery or radiation. BCR affects 30,000 to 50,000 men each year. Researchers want to know if a drug…
This is a multi-center, randomized, placebo-controlled, double blind clinical study to assess the efficacy and safety of two separate dose regimens of Alpha-1 MP versus placebo for 156 weeks (i.e., 3 years) using computed tomography (CT) of…
Hepatitis B virus (HBV) infection is a major public health threat in China. At present, a functional cure, also known as clinical cure or sustained Hepatitis B surface antigen (HBsAg) loss, is recommended as the ideal endpoint of HBV…
This phase II trials studies how well acalabrutinib with or without obinutuzumab works in treating patients with early-stage chronic lymphocytic leukemia or small lymphocytic lymphoma. Acalabrutinib may stop the growth of cancer cells by…
This pilot study will examine the safety, tolerability, acceptability, and efficacy of combination psilocybin + psychotherapy to decrease PTSD symptoms. Participants will be randomized into two different treatment groups, allowing the…
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Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
Delhi NCR-based NBFC Seeds Fincap raised more than ₹100 Cr ($10.4 Mn) in a Series B funding round led by…
The United Nations Development Programme (UNDP), with funding from the Global Fund’s COVID-19 Response Mechanism, has established two heavy-duty medical waste treatment and incineration facilities in Northern and Gedaref…
Seeds Fincap said it plans to use the latest funding to open more physical branches, hire field workers, and upgrade its risk tracking tools as it expands further into rural and semi-urban towns.
At the White House on Wednesday, Essar Group co-founder Ravi Ruia announced an $18 billion investment to build America’s largest steel plant in Iowa.
The manufacturing facility adds 135 million-unit annual capacity, with Carbapenem line now operational and validated under Biodeal’s ownership The post Biodeal Pharmaceuticals acquires Biological E facility, expands into…
Linux is a specialty-focused domestic formulations platform with a portfolio of over 125 brands spanning ~400 SKUs. The post Linux secures USD 70mn strategic investment from ChrysCapital and Tata Capital Healthcare Fund…
The agreement is expected to add South Africa to Elitecon’s international network and create additional employment at its Nashik plant.
The government will constitute a four-member committee headed by the Health Department Principal Secretary to prepare a draft bill for consideration by the state Assembly, Health Minister K Muraleedharan said on…
Union Minister of State for Agriculture and Farmers Welfare Ram Nath Thakur called for responsible use of pesticides and chemical fertilisers
BioStem Technologies Inc announced that it has entered into definitive agreements for the issuance and sale of 735,296 shares of the Company’s common stock, Series A warrants to purchase up to an aggregate of 735,296…
Kardigan™, Inc announced the appointment of Kristin Reinke to its Board of Directors, where she will serve as chair of the Audit Committee. As part of the Board’s public company evolution, Doug Giordano will be stepping…
Health systems have been utilizing artificial intelligence to help doctors detect diseases, and now a group of hospitals are banding together to share best practices. Twelve US hospital systems have teamed with Aidoc, an…
Healthcare organizations, on both sides of the provider-payer divide, expect to spend more on technology despite financial pressures. At the same time, their willingness to experiment with artificial intelligence is…
Getting patients to the right specialist at the right time can be a challenge, especially when symptoms are difficult to assess early on. Maurice O’Flaherty, a consultant trauma and orthopaedic surgeon who practices in…
Out-of-pocket spending on health care is one of the clearest measures of how much financial risk households bear when they fall ill. A new study by Sameer Sofi and Effat Yasmin, titled “Determinants of out-of-pocket…
“The healthcare sector is increasingly relying on advanced semiconductor technologies to enhance medical devices and diagnostic tools. This growing integration is transforming how healthcare data is processed and…
The Telangana Network Hospital Association (TANHA) has urged the State government to clear pending dues of about ₹2,000 crore to ₹2,500 crore owed to network hospitals under the Aarogyasri and other healthcare schemes,…
Two sustainability organisations, Solidaridad Network Asia and Solidaridad Southern Africa, have joined as partners to make sure the corridor is built on fair terms for farmers and without clearing forests
Noel Tata faces fresh challenges in the Tata Sons boardroom battle as SDTT vice-chairmen Srinivasan and Singh allege he advanced a restructuring plan without trustee consultation. Srinivasan has also challenged Noel’s…
AHPI said that while fixing a uniform 16 per cent margin can improve transparency and affordability, it should not be treated as a one-size-fits-all solution.
For the first time, trainers from India and Iran jointly prepared questions for practice tests that the two countries’ candidates took together
A Stanford University experiment called ‘xenocortication’ lets human brain tissue develop inside a living mouse, offering a novel way to study the developing human brain and, potentially, how disease develops. It also…
Regional Centre for Biotechnology-Department of Biotechnology (DBT), The Indian AI Research Organisation (IAIRO), and Indian Institute of Technology Gandhinagar (IITGN) convened a two-day workshop on Digital Twins for…
In addition to deep technical sessions, the conclave serves as a primary networking hub in India for Heads of analytical and research, scale-up, production, kilo labs, supply chain, policy makers, and academic leaders.…
Autophagy is a recycling process whereby a cell clears out or recycles unwanted objects by forming a recycling bin-like cavity called an 'autophagosome'. The "recycling bin" of the cell grows a lining which encloses the…
Merck & Co. touted a win for its anti-TL1A antibody in a phase 2b trial in patients with moderate to severe hidradenitis suppurativa (HS).
The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.
ai3Bio has emerged from stealth with $48 million in funding and a buzzing platform for targeting T cells in autoimmune disease.
Novo’s ongoing efforts to rejuvenate its pipeline have seen the Big Pharma turn to one of the most in-demand drug developers in China.
Varda secures this capital as drugmakers tout the potential of manufacturing in microgravity conditions to create differentiated medicines.
Life sciences and technology companies supported by the OBIO's CAAP have collectively raised more than $1bn in capital.
Abbott is kickstarting the U.S. commercial launch of SimpleScreen CRC, an FDA-approved blood-based colorectal cancer (CRC) screening test for adults age 45 and older who are at average risk for the disease.
As always, if you know of layoffs occurring at a biotech, please reach out to the Fierce Biotech editorial team.
The revelation of a patient death in Bristol Myers Squibb’s phase 3 trial of a potential pulmonary fibrosis treatment has raised concerns ahead of the study’s readout, but analysts were quick to dispel worries about…
Roche Diagnostics has launched a new in vitro diagnostic test for newborn screening to detect a series of rare disorders.
A more subdued volume of biopharma layoffs continued into the third quarter of 2026, validating predictions that the sector has moved beyond the avalanche of redundancies experienced last year.
Foghorn Therapeutics is laying off 40% of its workforce after a long-running collaboration with Eli Lilly collapsed over disappointing phase 1 data.
When recombinant DNA pioneer Herbert Boyer, Ph.D., first got a call from venture capitalist Robert Swanson about starting a company, the savvy scientist wasn’t sure a meeting would be worth his time.
A phase 3 trial of Boehringer Ingelheim’s survodutide in people with obesity and Type 2 diabetes has met its co-primary endpoints. Yet, with the readout echoing earlier data that underwhelmed analysts, shares in…
Sanofi is paying Regeneron $1 billion upfront to collaborate on four early-stage immunology programs, teeing the longstanding partners up to try to replicate Dupixent’s success.
Eli Lilly announced its amylin-Zepbound combination eloraTZP resulted in 23.3% weight loss in adults with type 2 diabetes and obesity or overweight, topping its own triple-G drug candidate retatrutide in that population.
Base editing biotech Beam Therapeutics is suing one of its newest rivals, alleging that the upstart company stole the secrets behind one of its lead programs and used them to craft a competing therapy.
GSK is paying Wave Life Sciences $12 million upfront to take ownership of a hepatic program arising from the companies’ long-running collaboration.
Highlight Therapeutics touted positive topline results in patients with localized high-risk head and neck basal cell carcinoma (BCC).
Connect Biopharma has pointed to phase 2 data for its IL-4/IL-13 blocker as proof that the wannabe Dupixent rival can reduce respiratory attacks—although the study missed a secondary endpoint tied to a breathing test.
The FDA has granted 510(k) clearance to Miami-based VertigoDx for its portable diagnostic system that can evaluate vertigo, including benign paroxysmal positional vertigo (BPVV).
Zealand Pharma has shared primary endpoint data on Roche-partnered petrelintide, revealing that the middle dose of the amylin analog delivered the highest weight loss—9.8%—at Week 28.
Amgen has shed light on its phase 2 lupus win, revealing that its monoclonal antibody daxdilimab was tied to a 6-point reduction in disease severity at the lower dose.
Eli Lilly has shared detailed data from a phase 3 retatrutide trial, revealing that more than one-third of patients on the top dose of the triple-G drug candidate lost at least 25% of their body weight.
A newly launched $5 million clinical trial program allows clinical trial sponsors to start trials in as little as 45 days in Ontario.
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