What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
Interest in precision medicine has accelerated efforts to identify sex-dependent responses to treatments and interventions. Those efforts have, both historically and today, been concentrated in fields related to the brain and behavior. Here, we show that even…
<title>Abstract</title> Crop yield prediction plays a very important role in productivity growth. Prediction of the crop yield in particular area helps the farmer to choose the right crop to be grown in the land. With crop yield prediction crop recommendation…
PURPOSE: To determine the prevalence of visual field (VF) defect among Indian driving licence (DL) holders and to evaluate their eligibility according to UK Driver and Vehicle Licensing Agency (DVLA) visual fitness standards. METHOD: Design: This…
Objective: To determine the incidence of and factors associated with magnetic resonance imaging (MRI)-detected postoperative spinal epidural hematoma after single-level unilateral biportal endoscopic (UBE) lumbar decompression with or without discectomy, and…
Tuberculosis of the craniovertebral junction (CVJ) is an uncommon condition, particularly in the pediatric population, and may present with severe neurological deficits due to instability and spinal cord compression. Surgical management is especially…
BACKGROUND & PURPOSE: Patients with diabetes mellitus undergoing coronary artery bypass grafting (CABG) with saphenous vein harvesting are at increased risk of impaired lower extremity perfusion and wound-related complications. Buerger-Allen exercises have…
Importance: Elevated low-density lipoprotein cholesterol (LDL-C) is a modifiable risk factor for cardiovascular disease, the leading cause of premature death worldwide. Assessing the LDL-C-related burden is critical for guiding prevention and treatment…
A field investigation was undertaken at M S Swaminathan School of Agriculture, Centurion University of Technology and Management, in the rainy period of 2024 to estimate the duration of the critical period for weed control (CPWC) of green corn under the…
Background: The cerebrospinal fluid tap test (CSF-TT) is widely used as an ancillary test to identify patients with idiopathic Normal Pressure Hydrocephalus (iNPH) for surgical management; however, its diagnostic utility remains unclear. We evaluate the…
Abstract Introduction Resistance to Mycobacterium tuberculosis (Mtb) infection despite known exposure varies among individuals, but the molecular mechanisms underlying this resistance remain poorly understood. It is unclear whether microRNAs (miRNAs) influence…
IntroductionAdenomyomatous hyperplasia (AH) of the Vaterian system is a rare benign lesion, often clinically mistaken for carcinoma and leading to unnecessary Whipple surgery.MethodsIn this multicentre cohort, Whipple pancreaticoduodenectomy specimens were…
Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in…
Abstract Background The Pacific Northwestern region of North America is inhabited by two distinct subspecies of black-tailed deer, Columbian ( Odocoileus hemionus columbianus ) and Sitka ( O. h. sitkensis ) black-tailed deer, which exhibit a complex…
Artificial intelligence (AI) is increasingly permeating healthcare, from serving as a physician assistant to powering consumer applications. The opacity of AI algorithms makes the ability of humans to interact with AI algorithms challenging. To overcome this…
The molecular mechanisms behind Dengue virus-dependent host pathogenesis, especially genome instability, remain largely unclear. This RNA virus causes a debilitating disease during active infection and presents future risks of postdengue syndromes, leukemia,…
Abstract Innate lymphoid cells (ILCs) are rare tissue-resident lymphocytes that functionally mirror cells of CD4 + T helper lineage but lack antigen receptors. Type 3 ILCs (ILC3s) are enriched at barrier sites, regulating inflammation and promoting tissue…
BACKGROUND: Extracranial bleeding is the most common complication of oral anticoagulant (OAC) therapy for atrial fibrillation (AF), but its clinical importance for patients may be underrecognized. We sought to characterize extracranial bleeding events…
Current methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-cell RNA sequencing (scRNA-seq) data, which can be misleading due to the poor cross-gene correlation (different…
The angiotensin II type I receptor (AT1R) is a G protein–coupled receptor that regulates the cardiovascular system and as a result is one of the most successful pharmacological targets for the treatment of hypertension. Within the angiotensin receptor…
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including semaglutide, produce robust and sustained weight loss, yet the central mechanisms supporting their long-term efficacy remain incompletely understood. Agouti-related peptide (AgRP) neurons of the…
BACKGROUND: Atherosclerosis is the primary underlying cause of coronary artery disease. LMOD1 is a coronary artery disease risk gene whose role in coronary artery pathophysiology is unknown. Whole-body loss of Lmod1 causes a lethal neonatal visceral myopathy…
Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two…
Ribosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly characterized. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA damage response (DDR)…
Abstract Nanobodies are powerful tools for modulating ion channels for mechanistic investigations and developing new therapeutics. The Kv1.3 channel is highly expressed in T-lymphocytes where it promotes sustained T-cell activation, its expression is elevated…
The deformability of cancer cells is a critical indicator of their malignancy, as this mechanical property of cancer cells can reflect various biostructural and biochemical changes such as the cytoskeletons and protein expressions. However, selectively…
Abstract Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions, but limitations in reproducibility, maturation and cell-type diversity persist. Especially, prolonged incorporation of mature microglia…
Microglial functional plasticity is shaped by metabolic and epigenetic reprogramming, but how these processes regulate central nervous system autoimmunity remains unclear. We find that cerebrospinal fluid lactate levels correlate with multiple sclerosis…
Abstract Polyamines, such as spermidine, are essential regulators of brain development, yet how cells control their uptake and extracellular levels remains unclear. Here we show that ATP13A4, a transport protein enriched in glia and prominently expressed in…
Abstract Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis. Instructed by environmental signals, type 1 conventional…
Mutations in transmembrane channel-like protein 1 (TMC1), the pore-forming component of the mechano-electrical transducer (MET) channel in auditory hair cells, cause cell death and deafness in 3-wk old mice. We studied mice with mutations Tmc1 p.T416K,…
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bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
Back-ground. Beneficial rehabilitation interventions for severely impaired stroke patients are limited. Owing to practical constraints in the routine clinical use of electroencephalogram (EEG)-based brain-computer interfaces, this study investigates the…
This systematic review and meta-analysis has several major aims, including evaluation of global and continent wise prevalence of diabetic peripheral neuropathies (DPNs), a detail assessment of DPN associated risk factors and most importantly to explore…
Background: The main cause of urinary tract infections (UTIs) are Gram negative bacteria with Escherichia coli as the leading cause and other important pathogens such as Klebsiella pneumoniae, Pseudomonas aeuriginosa and Enterococcus faecalis. Over the years…
Large language models (LLMs) can ease the work of screening titles and abstracts for systematic reviews, but obtaining reliable results requires researchers to make practical choices about which LLMs to use, how to combine their scores into a ranking, and how…
Shifts in flowering phenology are one of the most well studied plant responses to global climate change. Many studies have documented these shifts and their drivers, including some that describe altered patterns of co-flowering among taxonomically diverse…
Identifying synthetic lethal (SL) interactions offers a principled framework for discovering disease-specific therapeutic targets. However, current machine learning approaches heavily rely on curated protein-protein interaction networks. Because these networks…
Space-for-time Cormack-Jolly-Seber (CJS) models have been developed to estimate survival of migrating animals that are imperfectly detected at spatially discrete sampling stations. However, space-for-time CJS models typically ignore survival over time and…
BACKGROUND: Myofascial Pain Syndrome (MPS) is a common musculoskeletal pain condition associated with myofascial trigger points that has been reported to occur in 30-93% of patients who present with musculoskeletal pain. The current pharmacologic treatments…
BackgroundCardiovascular disease (CVD) is a leading cause of morbidity and mortality among individuals with diabetes, where risk remains elevated even with good glycemic control. Cardiac biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP),…
Mobile element insertions (MEIs) are a major source of structural variation in human DNA that can affect gene regulation and disrupt coding sequences. Population-scale MEI catalogs remain disproportionately skewed toward European-ancestry cohorts, with limited…
Contrast-enhanced computed tomography (CT) is central to the diagnosis, staging, and follow-up of patients with renal cell carcinoma (RCC). As artificial intelligence research into computer-aided solutions continues to grow, the need for curated and annotated…
The authors have withdrawn their manuscript because substantial revisions to the manuscript and major changes to the study design are required. Therefore, the authors do not wish this work to be cited as a reference for the project. If you have any questions,…
Autonomic dysfunction is a common sequela of mild traumatic brain injury (mTBI). Physical activity progression is an integral component of mTBI rehabilitation, particularly in addressing autonomic dysfunction. However, clinicians often rely on point-in-time…
Alzheimers disease pathology and cognitive outcomes frequently diverge, yet current single-axis definitions cannot identify resilient (high pathology, preserved cognition) and resistant (high risk, low pathology) subgroups reliably at scale, obscuring the…
Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of -synucleinopathies, but polysomnography is impractical for population-scale screening and questionnaires lack sufficient specificity. Beyond nocturnal movement, recently published…
Structural variants (SVs) contribute substantially to genetic and phenotypic diversity, but their characterization is far from complete. Inversions are particularly interesting because they affect recombination and could have negative consequences on…
Traditional clinical gait assessments focus on lower-limb kinematics and overall walking speed, often overlooking the upper-limb dynamics and inter-limb coordination that matter for real-world ambulation. Measuring these movements outside the laboratory is…
Abstract Background To estimate the frequency of likely, often undiagnosed autism and attention deficit hyperactivity disorder (ADHD) in UK adults of working age (18-66 years) who are not in education, employment, or training (NEET), and to examine whether…
Aims: To assess whether recent declines in U.S. rolling 12-month-ending drug overdose death counts are projected to continue, compare the retrospective performance of short-term forecasting models, and estimate national and regional 12-month changes. Design:…
Abstract Background Premature, or early-onset, coronary artery disease (CAD) carries lifelong consequences. Ethnic inequalities in CAD are established in the UK, but risk estimates mostly derive from events after middle age, while ethnicity is aggregated for…
Objective: Over the past decades, US policies intended to reduce air pollution emissions from electric generating units (EGUs), mobile sources (e.g., cars and trucks), and port activities have been implemented to improve air quality. This study aimed to…
The coexistence of competing pathogen strains is shaped by cross-immunity, the cross-protection that infection with one strain confers against another. Although cross-immunity is often asymmetric between strains, this asymmetry is often neglected in the…
Abstract Background The globally low birth weight is estimated to account for about 15-20% of all births. Global annual preterm delivery is about fifteen million, more than 60% of which occurs in Asia and Sub-Saharan Africa. The Kenyan preterm birth rate is…
BACKGROUND. In patients with venous thromboembolism (VTE), renal impairment increases the risks for both recurrence and bleeding. Because these patients are underrepresented in clinical trials, we assessed whether standard direct factor Xa inhibitor (DXI)…
Background. General purpose generative AI (GenAI) chatbots are increasingly used by students for mental health support. Research on prevalence estimates vary widely, rarely link use to validated clinical measures, and have not been reported in a Canadian…
Background Hepatitis B virus (HBV) is a global health concern and the leading cause of chronic liver disease, including liver cirrhosis and hepatocellular carcinoma. The Uganda Ministry of health recommends screening of HBV for all pregnant mothers during…
Disinfection with bleach is recommended for surface cleaning in healthcare facilities, but bleach degrades over time, reducing disinfection effectiveness. We evaluated whether local bleach produced by hospitals using novel technology had adequate shelf life to…
Purpose: To build a 3D U-Net model, BioDeformUNet, to predict the deformation vector field (DVF) of the liver in near real-time, for efficient intra-procedural evaluation of the minimal ablative margin (MAM). Materials and Methods: This retrospective study…
Existing radiological artificial intelligence (AI) systems are difficult to modify, validate, and adapt to new clinical applications. We present a large language model (LLM)-driven agentic framework capable of reconstructing, optimizing, and customizing…
Background: As medicine grows increasingly technological and scientific, biomedical researchers working to bring new knowledge to bear on clinical practice face a key question: when is a new intervention or treatment ready for clinical use? Because this is…
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Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
The study will assess the efficacy and safety of 2 dose regimens of pegozafermin compared to placebo for the treatment of liver fibrosis stage F2 or F3 in adult participants with MASH.
The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates for…
The study will assess the efficacy and safety of pegozafermin administered in participants with compensated cirrhosis due to MASH (biopsy-confirmed fibrosis stage F4 MASH \[previously known as nonalcoholic steatohepatitis, NASH\]).
In this study, researchers will learn more about the use of felzartamab in participants with immunoglobulin A nephropathy (IgAN). IgAN is a kidney disease caused by the buildup of an antibody called IgA in the kidneys over time. In people…
This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib,…
The main aim of this study is to find out how well elritercept works to improve anemia in participants with myelofibrosis (MF) who are taking ruxolitinib when compared to placebo. Other aims are to learn how elritercept improves anemia…
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the…
The goal of this clinical trial is to test the safety and effectiveness of a single dose of RABI-767 given by endoscopic ultrasound (EUS) guided peripancreatic injection in participants with predicted severe acute pancreatitis. The main…
This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative…
The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week placebo-controlled treatment period in…
The reason for this study is to see if the study drug called baricitinib works and is safe in children and teenage participants with atopic dermatitis.
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background of…
This research is being conducted to asses if HT-6184 is effective in the treatment of Very Low, Low, or Intermediate Risk Myelodysplastic Syndrome (MDS) and Symptomatic Anemia. The study includes a 28-day Screening Period followed by a 16-…
A global study to assess the efficacy and safety of osimertinib following chemoradiation in patients with stage III unresectable Epidermal Growth Factor Receptor Mutation Positive non-small cell lung cancer
A5409/RAD-TB is an adaptive Phase 2 randomized, controlled, open-label, dose-ranging, platform protocol to evaluate the safety and efficacy of multidrug regimens for the treatment of adults with drug-susceptible pulmonary tuberculosis (TB).…
This is a multicenter trial with recruitment planned at ophthalmology clinics specializing in corneal diseases in India, Brazil, and at Stanford University and Bascom Palmer Eye Institute in the United States. Fusarium keratitis is common…
This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (also known as RO7790121) in participants with moderately to severely active Crohn's disease…
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron and dapagliflozin in combination, compared with elecoglipron alone and dapagliflozin alone, in adults with type 2 diabetes mellitus (T2DM)…
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with placebo in adults with Type 2 Diabetes Mellitus (T2DM), treated with a background insulin and other background glucose-lowering…
Migraine is a common, heterogeneous neurological disorder affecting approximately 10-15% of the global population and is the third most prevalent disease worldwide. A wide range of pharmacological agents is available for migraine…
The North Star study is a multi-center, Phase 3, open-label, single-arm clinical study to evaluate the Efficacy and Safety of North Star therapy.
28 participants are expected to be enrolled for the Phase II clinical trial, this trial is expected to be finished in 36 months.
Brief Summary of Stage 1: The purpose of Stage 1 (Phase I/IIa) was to assess the safety and immunogenicity of a single intramuscular (IM) injection of 3 dose-levels of an Respiratory Syncytial Virus (RSV) vaccine candidate formulated with 2…
Background: Prostate cancer is the second most common cause of cancer-related death among men in the United States. Early-stage, low-grade prostate cancer is managed with active monitoring. However, 35% of men with this cancer will need…
This phase II trial evaluates whether genetic testing in prostate cancer is helpful in deciding which study treatment patients are assigned. Patient cancer tissue samples are obtained from a previous surgery or biopsy procedure and tested…
Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as Autoimmune polyendocrine syndrome type-1 (APS-1), is a disease that causes the immune system to attack parts of a person's body. In some…
The purpose of this clinical trial is to evaluate efficacy and safety of tirabrutinib alone compared with rituximab and temozolomide (R-TMZ) combination therapy in participants with Relapsed/Refractory Primary Central Nervous System…
This study is designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC).
This study is researching an experimental drug called REGN7945 in combination with another experimental drug called linvoseltamab, (also known as REGN5458) (each individually called a "study drug" or "study drugs" when combined). This study…
This is a Phase 2, randomized two-armed, multi-site study of 170 patients with newly diagnosed glioblastoma multiforme. Patients will be randomized 1:1 to receive Keto Diet, or Standard Anti-Cancer Diet. All patients will receive standard…
The purpose of this study is to assess how well JNJ-95597528 works when compared to placebo in adult participants with moderate to severe asthma (long-term condition that affects the airways in your lungs).
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients with…
The purpose of the study is to assess how well each dose of lumateperone (Dose 1 and 2) works when given alone as compared to placebo in participants with major depressive disorder (MDD; a medical condition characterized by a persistent…
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage…
CO43923 is a platform study that will evaluate the safety, efficacy, and pharmacokinetics (PK) of multiple treatment combinations, as monotherapy or in combination, in participants with multiple myeloma (MM). The study is designed with the…
This phase III trial compares the effect of vorasidenib to placebo in combination with usual treatment, temozolomide, in treating patients with newly diagnosed grade 3 astrocytoma after radiation. Temozolomide is in a class of medications…
This is an open-label, multicenter, Phase 2 study designed to evaluate the efficacy and safety of AHB-137 injection in participants with chronic hepatitis B (CHB) with low hepatitis B surface antigen (HBsAg) levels.
In the first part of this study we found the highest dose of the vaccine that did not have too many side effects. We are now trying to find out what effects the vaccine has when given at the same dose to all patients. The main treatment in…
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation…
This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants…
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Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
The transaction includes a sale of 100% stake by existing shareholders, as well as a commitment to deploy fresh capital to fund its growth and repay debt. In all, KKR will be spending Rs 13,000-14,000 crore, around…
Imports from Asean increased by 14% to nearly Rs 13,000 crore FY25-26, led by syringes, medical gloves, dialysis products, consumables and imaging equipment, including X-ray machines, making it harder for companies to…
Its net profit was at ₹55.50 crore in the year-ago period
IPO comprises an offer for sale by promoters and investor selling shareholder through the book-building process. The post Encube Ethicals files DRHP with SEBI for Rs 3,000 crore IPO appeared first on Express Pharma .
The collaboration brings together Neuland’s API development capabilities and Gland Pharma’s sterile manufacturing expertise to support demand for sterile APIs used in microparticle depot products The post Gland Pharma,…
Ebola has killed more than 1,700 people in eastern Congo in the fastest-growing outbreak of the disease, data showed. As of Tuesday, 3,802 cases had been recorded, with 1,707 deaths, according to the latest government…
The Centre has sent a National Joint Outbreak Response Team (NJORT) to Gujarat and Rajasthan to bolster the response to the ongoing Chandipura Virus Disease (CHPV) outbreak, which has claimed the lives of at least 22…
The Department of Pharmaceuticals (DoP) has cancelled the Request for Proposal (RFP) for the study titled Sectoral Plan for Efficient Logistics (SPEL). The RFP was intended to develop a comprehensive logistics plan for…
The Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Government of India, in collaboration with the Federation of Indian Chambers of Commerce & Industry (FICCI), is set to host the 9th edition of India…
The All India Institute of Medical Sciences (AIIMS), Delhi, recalled certain batches of disposable syringes earlier this year as a precautionary measure after receiving quality-related complaints from user departments,…
Tamil Nadu’s maiden FY27 Budget under the TVK government has earmarked Rs 23,357 crore for the Health and Family Welfare Department, signalling continuity with the State’s long-standing focus on public health and a…
India on August 3 launched a real-time digital platform to manage organ donation and transplantation, marking one of the biggest reforms to the country’s transplant ecosystem in years. Unveiled by the National Organ and…
The Odisha government on Tuesday signed memoranda of understanding (MoUs) with 10 organisations for advancing healthcare delivery, innovation and institutional collaboration. The state Health and Family Welfare…
Michigan health officials on Tuesday reported 11,508 cases linked to a cyclosporiasis outbreak, up by more than 200 from the previous day’s update. The state also reported the first two deaths associated with the…
NITI Aayog released the report titled “Reimagining Care: Strategies for Empowering Caregivers in Viksit Bharat@2047” at NITI Aayog. The report presents India’s caregiving ecosystem and outlines a comprehensive roadmap…
Findings published in the journal Annals of the Rheumatic Diseases underscore the importance for healthcare providers and policymakers to recognise the impact air pollution can have on how one manages the condition.
As per the Agriculture Ministry data, the All India average wholesale mandi prices of urad have eased to Rs 8,638 per quintal as of August 3
The Bengaluru-based company builds models that generate molecules and predict how they will behave, and has licensed its lead candidate to a US developer.
The Bengaluru company is building AI software that models microbial fermentation, so manufacturers can scale a process without discovering its problems in production.
The conference brings together stakeholders from across the rice value chain, including exporters, importers, millers, traders, policymakers, researchers, logistics companies, financial institutions and technology…
The vigorous wind regime is also expected to sustain strong surface winds and frequent showers along stretches of the west coast and the interior peninsula
Findings also show stillbirths may tend to occur around the 29th week of gestation among pregnant women with severe anaemia, compared to 31st week of gestation among other women.
Natco claims the new patent unlawfully extends Novartis’s market monopoly over the breast cancer medicine past 2027; Delhi High Court issues notices to all parties.
India's next export wave will not be won on tariff advantage alone; mutual recognition of standards and regulatory cooperation will play vital roles. The post Diversifying beyond the US market appeared first on Express…
Eli Lilly has axed another trial of a gene therapy acquired in its $1 billion Prevail Therapeutics buyout, further denting the drugmaker’s chances of delivering a return on its investment.
Expedition Therapeutics has secured an oversubscribed $115 million series B financing from a line-up of big-name investors to propel its lead DPP1 inhibitor through phase 2.
Attovia Therapeutics has accreted a hefty $289 million from its IPO to power its anti-itch drugs through clinical development, marking another upsized listing in what has become a banner year for biotech Nasdaq debuts.
Private equity giant KKR is expanding its healthcare portfolio with a deal to take medtech manufacturing giant Integer private for approximately $5.7 billion.
Latigo Biotherapeutics has fleshed out its plans for an IPO to finance the development of its clinical-stage pipeline of non-opioid pain management drugs.
Pathos AI has agreed to pay $125 million for a bispecific antibody-drug conjugate from China’s Alphamab Oncology, while adding a Big Pharma partner in the form of AstraZeneca.
Months after reports first linked Curium to a potential Lantheus takeover, the radiopharma players have made it official with a deal worth up to $8 billion.
BlossomHill Therapeutics plans to raise $111.7 million to fund the clinical journey of its potential challenger to Tagrisso.
The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.
This funding round will set Mironid up until the generation of initial clinical data, the company’s CEO says.
Biologics CDMO AsymBio is set to secure $184m in funding from Asymchem Group, Hillhouse Qirui and other investors to support long-term growth.
Two and a half years into his tenure as Emergent BioSolutions CEO, Joseph Papa is executing another round of restructuring to align the business with “current business realities.”
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce has learned.
Fecal transplants can increase tolerance to peanuts sixfold in people with food allergies, new research out of Boston Children’s Hospital has suggested.
Novo Nordisk’s CEO admitted the Danish pharma has had “a couple of setbacks” in the wake of mixed data for CagriSema and its cardiovascular hopeful ziltivekimab, while stressing that the company is already on the hunt…
Contract research organization Icon announced a multi-year collaboration with Anthropic this week to bring Claude’s AI capabilities to clinical trials.
Amgen has ended development of its early-stage obesity drug AMG 513, foisting its hopes for a slice of the massive weight loss market onto the shoulders of phase 3 candidate MariTide.
Smith & Nephew has lowered its 2026 sales outlook after weakness in U.S. orthopedics and wound care outweighed stronger growth in sports medicine.
Who should be a 2026 Fiercest Woman in Life Sciences? Nominations are open for women making an impact across pharma, biotech, medtech and beyond. The deadline is Sept. 18.
Lisata is laying off 72% of its workforce, including its chief medical officer, as the solid tumor biotech tries to navigate a new future after a planned merger with cancer imaging company Kuva Labs fell apart.
Pfizer has axed two clinical-stage obesity programs, dropping a GLP-1 receptor agonist from the Metsera buyout and a GIPR antagonist as part of its quarterly pipeline cleanout.
A phase 2 trial of Merck & Co.’s anti-TL1A monoclonal antibody has missed its primary endpoint, closing off one avenue for expansion of an asset acquired in a $10.8 billion takeover. The setback was offset by a…
Not content with navigating Rezdiffra’s trajectory to blockbuster territory, Madrigal Pharmaceuticals has spent 2026 shopping for a range of drugs that the company hopes could work alongside its metabolic…
One of the most closely watched vacancies in biopharma has now been filled, with Sobi CEO Guido Oelkers, Ph.D., moving across to take up the top job at mRNA pioneer BioNTech.
Combining the two drugmakers would trigger severe regulatory concerns and significant pipeline disruptions, cost numerous jobs, all while damaging the broader biopharma ecosystem and hurting patients, Angus Liu argues in…
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