What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
Introduction Nearly 15% of couples worldwide experience infertility, with Male Infertility (MI) accounting for 30–50% of these cases. Despite this burden, research on MI lags behind female infertility, particularly in understanding how demographic, clinical,…
Introduction Access to mechanical thrombectomy (MT) remains limited in many low- and middle-income or resource-limited regions because of gaps in trained personnel, procedural experience, public awareness, and stroke-system readiness. The World Stroke…
In 2023, tuberculosis (TB) once again became the world's deadliest infectious disease, overtaking COVID-19 as the leading cause of death from a single infectious agent, Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) reports that the…
The GLP-1 receptor agonist semaglutide preserves kidney function in people with type 2 diabetes and chronic kidney disease, but the underlying mechanisms are unclear. Here we report a 52-week randomized trial of subcutaneous semaglutide 1 mg once weekly versus…
This cross-sectional study examines glucagon-like peptide-1 (GLP-1) receptor agonist initiation rates among postpartum women with commercial insurance in the US.
BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort…
Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We…
BACKGROUND: The Darjeeling Hill Region (DHR) has numerous freshwater bodies, such as hill streams, springs, and temporary water pools. It receives abundant rainfall and has extensive forest cover, which together play vital roles in sustaining frog diversity.…
In this study, we describe two new species of the genus Folsomia from the Nilgiris, Western Ghats, India, F. ciega sp. nov. and F. unioculata sp. nov. Some notes on F. penicula Bagnall, 1939, and a redescription of F. arunachalensis Mandal, 2018 are included.…
Background Gingivitis can be found in up to 90% of the population with dental plaque being the primary cause and chemical approaches such as antimicrobial mouth washes, for eliminating plaque, are suggested for either supplementing the mechanical removal of…
BACKGROUND: Acute motor and sensory axonal neuropathy is a rare, severe variant of Guillain-Barré syndrome marked by rapid progression, autonomic dysfunction, and delayed recovery. The patient in this report was treated in a resource-limited intensive care…
Abstract Background Accurate classification of brain tumors from magnetic resonance imaging (MRI) is critical for effective clinical diagnosis and treatment planning. Although deep learning models such as convolutional neural networks and vision transformers…
BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced…
Abstract Ribosome hibernation helps cells survive stress by reversibly silencing translation and preserving ribosomal complexes. Although well characterized in bacteria and eukaryotes, archaeal hibernation remains poorly understood. Using cryoEM of archaeal…
The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ∼1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific…
Abstract Background G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read…
Human tumor-associated microbes – the tumor microbiome – have demonstrated an increasingly important role in human health due to their relevance to cancer progression and treatment response. While the metabolism at the host-microbiota interface, such as in the…
Antithrombotic therapy undertreatment includes omission, nonadherence, underdosing, and clinical circumstances that result in subtherapeutic antithrombotic levels. Antithrombotic undertreatment has profound implications for patient safety, public health, and…
Trypanosoma brucei and Leishmania tarentolae are model kinetoplastids whose mitochondria contain a unique DNA network, kinetoplast DNA (kDNA), and exhibit specialized features, including developmental remodeling and RNA editing. By integrating mass…
Abstract Pulse Electron Paramagnetic Resonance (EPR) spectroscopy provides powerful tools for examining species with unpaired electrons, such as organic radicals and metal ions, in a wide variety of interesting systems. However, the lack of high power pulse…
Multiple sclerosis (MS) is an autoinflammatory disease of the central nervous system (CNS). Epstein–Barr virus (EBV) encodes for EBNA-1 381-452 , which induces autoreactive immune responses against distinct CNS derived proteins (GlialCAM 370-389 , CRYAB 2-21 ,…
True polar wander (TPW) is presently occurring at a rate of ~10 centimeters per year, exceeding the mean rate of differential plate motion. Whether this rate is transient and negligible on geological timescales or whether Earth has experienced rapid TPW…
Abstract Hemoglobinopathies are the most common inherited anemias worldwide. While most carriers are asymptomatic or mildly affected, severe forms of α-thalassemia, including severe hemoglobin H (HbH) disease and surviving individuals with Hb Bart’s hydrops…
Although tumor protein p53 ( TP53 ) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we found that p53 suppresses clonal expansion by limiting…
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bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
Long-term cognitive outcomes following COVID-19 remain poorly characterized in South Asian populations. We assessed 181 Indian adults---99 with a reported history of COVID-19 at least six months earlier and 82 healthy controls---using standardized tests of…
Background Oral glucose tolerance test (OGTT), the gold standard for diagnosing gestational diabetes mellitus (GDM), faces significant implementation challenges, prompting interest in alternative biomarkers, such as glycated hemoglobin (HbA1c), for early…
Endosomal dysfunction is a presymptomatic hallmark of neurodegeneration. Recent evidence highlights dysregulation of endosomal pH as a central pathogenic hub in Alzheimer's disease (AD); however, the mechanisms linking pH shifts to neurodegeneration remain…
Cell division is fundamental to multicellular organisms, and stochastic partitioning of cellular components can strongly affect genome-wide gene expression. However, how cell division-associated stochasticity shapes cellular dynamics is poorly understood.…
{beta} cell expression of the immune checkpoint ligand PD-L1 (encoded by CD274) limits autoimmune {beta} cell destruction in type 1 diabetes (T1D). {beta} cell display PD-L1 not only at the cell surface but also secreted on extracellular vesicles (EVs), which…
Routine facility-based testing for hepatitis C virus (HCV) remains underutilised in India despite national screening policy. WHO has recommended HCV self-testing (HCVST) since 2021 to increase access to testing services. This study evaluated the HCVST by…
BackgroundDetermining the cause of death in electrocution is often challenging at autopsy, particularly when characteristic external electrical marks are absent. Reliable internal markers are scarce, and the neuropathological changes associated with…
Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not…
Background: The uptake of new digital and AI based technologies in the health care setting, including digital diagnostics, has been comparatively slower than in other sectors. This is a consequence of the complex legislature, lack of routine procedures for the…
ABSTRACT Introduction The prevalence of chronic heart failure is increasing in Singapore and is associated with frequent hospitalisations, high costs, and impaired quality of life. Patient empowerment interventions for chronic diseases, which are structured…
Subcallosal cingulate cortex (SCC) deep brain stimulation (DBS) can provide relief for individuals with Treatment Resistant Depression (TRD), but ongoing clinical management remains challenging due to nonspecific symptom fluctuations that can obscure core…
Background: Post-COVID Condition (PCC) affected 10-30% of individuals after SARS-CoV-2 infection, and pre-infection predictors of who goes on to develop it are not well established. We compared pre-infection structural brain variation and baseline psychiatric…
Understanding the genetic architecture of schizophrenia (SCZ) is invaluable for the development of personalized treatment. In three independent cohorts, using an automated pipeline, we calculated 413 psychiatry-relevant polygenic scores. Using these scores,…
Abstract Background: Plethysmometry is a cuff based method that records photoplethysmographic pulse amplitudes at multiple cuff pressure levels and estimates ranges of systolic and diastolic blood pressure together with mean arterial pressure. Objective: To…
Summary Background The National Early Warning Score (NEWS) is widely used to predict patient deterioration, but retrospective validations face intervention bias and emphasise discrimination over clinical utility. We aimed to compare NEWS's clinical net benefit…
Objectives: Assess bacterial isolate aetiology, antimicrobial (AMR) and multidrug (MDR) resistance trends, cultured from patients with infectious keratitis at a tertiary referral hospital in South India. Methods: This retrospective study examined all-bacterial…
Current evidence supports resistance training for stroke recovery but autonomic dysregulation following stroke can lead to exaggerated fluctuations in blood pressure (BP) in response to exercise, thus challenging perceptions about safety and feasibility of…
Healthcare workers face substantial occupational demands and exposure to respiratory infections during winter, but evidence that probiotics improve their health and wellbeing remains limited. This exploratory, double-blind, randomised, placebo-controlled trial…
Background/Aims This work aimed to estimate the annual tertiary healthcare and societal costs associated with paediatric congenital heart disease (CHD) in the United Kingdom using real-world data from a Level 1 cardiac surgical centre in the National Health…
Post-treatment Lyme disease syndrome (PTLDS) is characterized by persistent symptoms after antibiotic therapy for Borrelia burgdorferi infection. The mechanisms underlying these symptoms remain incompletely understood and have been attributed to ongoing…
Age of first alcohol use is associated with alterations in brain development and an increased risk of problematic substance use later in life. However, it remains unclear if neurobiological alterations associated with first-use age are present in young…
Background: Mitral valve prolapse (MVP) causes mitral regurgitation (MR), leading to volume overload and maladaptive left ventricular (LV) remodelling. Objective: To comprehensively characterize markers of maladaptive LV remodelling across MR severity grades…
Background: Racial disparities in incident heart failure (HF) are well documented, yet the extent to which systemic inflammatory burden-shaped by structural determinants of environmental exposure-accounts for these disparities remains unquantified in…
Objective To evaluate the information quality, reliability, readability, and content deficits of ChatGPT, DeepSeek, and Doubao in answering frequently asked questions about bee stings. Methods Twenty-five high-frequency patient questions were selected based on…
Abstract Continuous glucose monitoring (CGM) is recommended for type 1 diabetes, but the supporting evidence derives almost entirely from high-income settings, and the technology is not routinely available in Kenya's public sector. This prospective study…
Background: Pertussis has resurged in the post-COVID-19 era, yet diagnostic delay remains a barrier to timely treatment and transmission interruption, particularly among adults. Methods: Retrospective observational cohort study of 787 patients with confirmed…
Background: Millions of textile and agricultural workers inhale organic dust containing endotoxin, an exposure associated with impaired respiratory function. However, the underlying biological pathways remain unclear. We conducted a two-cohort epigenome-wide…
Background and Objectives: Influenza vaccination has a strong safety record and is effective in reducing pediatric influenza-associated morbidity and mortality. However, pediatric vaccination coverage (VC) has declined since the 2019/20 influenza season in the…
Background. Large language models (LLMs) are increasingly used to support systematic review and meta-analysis, but complex evidence flow, trial-family identification, study-level data extraction, and statistical execution remain vulnerable to omissions,…
Abstract: Background: Children born very preterm (VPT) are at elevated risk for adverse neurobehavioral outcomes and are vulnerable to environmental exposures. We used untargeted metabolomics analysis to identify environmentally relevant metabolites associated…
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Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome…
In this study, researchers will learn more about omaveloxolone, also known as BIIB141 or SKYCLARYS®. Omaveloxolone is already approved for people with Friedreich's Ataxia (FA) who are 16 years of age or older. However, it is not yet…
Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with…
The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia…
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
The purpose of this study is to provide continued access to anifrolumab to eligible participants who are continuing to derive clinical benefit from treatment at the end of a parent clinical study, as assessed by the Investigator, while…
This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.
The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival…
This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal…
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy…
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is…
This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative…
Voltage Gated Sodium Channels Over the years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage gated sodium channels (VGSC) expressed in non-nervous or non-muscular organs are often…
Triple-negative breast cancer is a subtype of breast cancer that is clinically negative for expression of estrogen and progesterone receptors (ER/PR) and HER2 protein. It is characterized by its unique molecular profile, aggressive…
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they…
The overall purpose of this two-part study is to evaluate the efficacy, safety and tolerability of iptacopan (LNP023) in addition to standard of care treatment.
This study is open to adults who are at least 18 years old living with obesity and have: * a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and * moderate or advanced liver…
This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations). The purpose of this study is to find out…
This study is open to adults who are at least 18 years old and have: * A confirmed liver disease called non-alcoholic steatohepatitis (NASH) or * A confirmed liver disease called metabolic-associated steatohepatitis (MASH) * BMI of 27 kg/m2…
This study is open to adults with systemic lupus erythematosus (SLE). The purpose of this study is to find out whether a medicine called BI 3000202 helps people with SLE. The study tests different doses of BI 3000202 and aims to find the…
This study is a multicenter, randomized, double-blind, positive parallel controlled phase III clinical trial to compare efficacy, immunogenicity, pharmacokinetics, pharmacodynamics and safety of omalizumab α(CMAB007) and Xolair® in patients…
Phase 2 study to assess the efficacy of topically administered eyedrops of INV-102 during a 12-week dosing period in subjects with non-center involved DME (NCIDME) associated with NPDR \[Part 1\] and during an 8-week dosing period in…
This phase III trial compares the addition of total ablative therapy to the usual systemic therapy versus the usual systemic therapy alone in treating patients with advanced colorectal cancer that has spread to up to 4 body sites (limited…
The investigators propose to develop and test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
Background: Sjogren disease is an autoimmune disease - that is, a disease that causes the body's immune system to attack its own organs and tissues. Sjogren disease can affect the kidneys, lungs, or other organs. It can also cause dry mouth…
Background: \- Plexiform neurofibromas are tumors that grow in and around nerves. The only way to treat them is with surgery. Some of these tumors cannot be completely removed. The tumors may be too large, too numerous, or in a bad location…
The primary objective of the trial is to describe the long-term safety and tolerability of TEV-56286 administered orally for the treatment of adult participants with Multiple System Atrophy (MSA). A secondary objective of the trial is to…
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD). While current surgical therapies successfully reattach…
This research study is studying a combination of drugs as a possible treatment for breast cancer that has tested positive for a protein called HER2. The names of the study interventions involved in this study are: * Trastuzumab emtansine…
Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals. In people without alcohol use disorder (AUD), CBD has been show to be effective in…
This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG).
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab,…
The purpose of this study was to determine the antitumor activity of enfortumab vedotin (EV) confirmed by the objective response rate (ORR). This study also evaluated the effect of antibody-drug conjugate (ADC), total antibody (TAb) and…
Background: \- Many people who have traumatic brain injury (TBI) have low levels of physical fitness. Low physical fitness causes severe fatigue that reduces the ability to perform routine daily activities, and may also cause increased…
The study, led by Zhejiang Cancer Hospital and sponsored by Bio-Thera Solutions, Ltd., is an exploratory multicenter, open-label phase Ib-II clinical trial evaluating the safety, tolerability, pharmacokinetic characteristics, and…
This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal…
Background: Shingles is a painful, blistering rash caused by the same virus that causes chickenpox. Shingrix is a vaccine approved to prevent shingles in healthy adults over age 50 and in immunocompromised adults over age 18. Researchers…
The main purpose of this trial is to find out whether BHB-1893 works better than metoprolol in adults with symptoms of obstructive hypertrophic cardiomyopathy (oHCM). The trial includes adults who are currently being treated for oHCM or who…
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III study with an open-label extension. The purpose is to evaluate efficacy and safety in adult patients with chronic hepatitis B virus infection who have received at…
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Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
Delhi NCR-based NBFC Seeds Fincap raised more than ₹100 Cr ($10.4 Mn) in a Series B funding round led by…
The United Nations Development Programme (UNDP), with funding from the Global Fund’s COVID-19 Response Mechanism, has established two heavy-duty medical waste treatment and incineration facilities in Northern and Gedaref…
Seeds Fincap said it plans to use the latest funding to open more physical branches, hire field workers, and upgrade its risk tracking tools as it expands further into rural and semi-urban towns.
The manufacturing facility adds 135 million-unit annual capacity, with Carbapenem line now operational and validated under Biodeal’s ownership The post Biodeal Pharmaceuticals acquires Biological E facility, expands into…
Linux is a specialty-focused domestic formulations platform with a portfolio of over 125 brands spanning ~400 SKUs. The post Linux secures USD 70mn strategic investment from ChrysCapital and Tata Capital Healthcare Fund…
The shift comes as whey protein, a key ingredient in conventional supplements, becomes more expensive. Industry executives said whey protein powder now costs more than ₹4,500 a kg, up from around ₹1,000 in 2023.
Addressing the inaugural session of the International Conference of the Society of Robotic Surgery, Singh said robotics, along with AI and nanoscience, would create a larger ecosystem for precision health delivery and…
Noida-based Yatharth Hospital and Trauma Care Services operates a network of super-speciality hospitals in India, providing comprehensive healthcare services, diagnostics, and advanced medical procedures across multiple…
In the study, Nfonsam and colleagues reviewed data on 15,774 patients diagnosed with acute appendicitis who underwent appendectomy and another 15,295 who were treated with antibiotics alone.
As the harvesting season peaks, farmers in the rice-growing belts of Anantnag, Kulgam, Pulwama and Ganderbal are reporting a marked improvement in crop output, raising hopes of better returns after successive years of…
The government will constitute a four-member committee headed by the Health Department Principal Secretary to prepare a draft bill for consideration by the state Assembly, Health Minister K Muraleedharan said on…
Union Minister of State for Agriculture and Farmers Welfare Ram Nath Thakur called for responsible use of pesticides and chemical fertilisers
Integrating the Farmer Health Capital Theory into agricultural policy offers a sustainable path to secure farmer welfare and future-proof Maharashtra’s agrarian economy
Empowering farmers with better information and smarter decisions can ultimately strengthen both agricultural productivity and rural livelihoods
BioStem Technologies Inc announced that it has entered into definitive agreements for the issuance and sale of 735,296 shares of the Company’s common stock, Series A warrants to purchase up to an aggregate of 735,296…
Kardigan™, Inc announced the appointment of Kristin Reinke to its Board of Directors, where she will serve as chair of the Audit Committee. As part of the Board’s public company evolution, Doug Giordano will be stepping…
Health systems have been utilizing artificial intelligence to help doctors detect diseases, and now a group of hospitals are banding together to share best practices. Twelve US hospital systems have teamed with Aidoc, an…
Healthcare organizations, on both sides of the provider-payer divide, expect to spend more on technology despite financial pressures. At the same time, their willingness to experiment with artificial intelligence is…
Getting patients to the right specialist at the right time can be a challenge, especially when symptoms are difficult to assess early on. Maurice O’Flaherty, a consultant trauma and orthopaedic surgeon who practices in…
Out-of-pocket spending on health care is one of the clearest measures of how much financial risk households bear when they fall ill. A new study by Sameer Sofi and Effat Yasmin, titled “Determinants of out-of-pocket…
“The healthcare sector is increasingly relying on advanced semiconductor technologies to enhance medical devices and diagnostic tools. This growing integration is transforming how healthcare data is processed and…
The Telangana Network Hospital Association (TANHA) has urged the State government to clear pending dues of about ₹2,000 crore to ₹2,500 crore owed to network hospitals under the Aarogyasri and other healthcare schemes,…
Two sustainability organisations, Solidaridad Network Asia and Solidaridad Southern Africa, have joined as partners to make sure the corridor is built on fair terms for farmers and without clearing forests
AHPI said that while fixing a uniform 16 per cent margin can improve transparency and affordability, it should not be treated as a one-size-fits-all solution.
For the first time, trainers from India and Iran jointly prepared questions for practice tests that the two countries’ candidates took together
When Xaira Therapeutics first debuted in 2024 with a gobsmacking $1 billion in funding, a natural expectation would have been for a flurry of further activity to follow. Instead, the buzzy AI biotech went quiet.
Novartis is paying Abogen Biosciences $575 million upfront for an mRNA-encoded T-cell engager that showed early clinical promise in autoimmune disease. The deal, which includes up to $7.2 billion in milestones, comes…
Merck & Co. touted a win for its anti-TL1A antibody in a phase 2b trial in patients with moderate to severe hidradenitis suppurativa (HS).
The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.
Unlike other therapies in this class, Abogen’s ABO2203 is designed to produce a T-cell engager protein in vivo through an mRNA-encoded system.
Varda secures this capital as drugmakers tout the potential of manufacturing in microgravity conditions to create differentiated medicines.
Eric Cantor, who represented Virginia in the U.S. House of Representatives for 14 years and served as House majority leader from 2011 to 2014, will step up as PhRMA’s next president and CEO on Nov. 9. Plus, Bayer has a…
Adecto Pharmaceuticals’ 12-year story has come to an end as the immunotherapy biotech blamed a “risk-averse funding environment” for shutting up shop.
Abbott is kick-starting the U.S. commercial launch of SimpleScreen CRC, an FDA-approved blood-based colorectal cancer (CRC) screening test for adults age 45 and older who are at average risk for the disease.
As always, if you know of layoffs occurring at a biotech, please reach out to the Fierce Biotech editorial team.
The revelation of a patient death in Bristol Myers Squibb’s phase 3 trial of a potential pulmonary fibrosis treatment has raised concerns ahead of the study’s readout, but analysts were quick to dispel worries about…
Roche Diagnostics has launched a new in vitro diagnostic test for newborn screening to detect a series of rare disorders.
A more subdued volume of biopharma layoffs continued into the third quarter of 2026, validating predictions that the sector has moved beyond the avalanche of redundancies experienced last year.
Foghorn Therapeutics is laying off 40% of its workforce after a long-running collaboration with Eli Lilly collapsed over disappointing phase 1 data.
When recombinant DNA pioneer Herbert Boyer, Ph.D., first got a call from venture capitalist Robert Swanson about starting a company, the savvy scientist wasn’t sure a meeting would be worth his time.
A phase 3 trial of Boehringer Ingelheim’s survodutide in people with obesity and Type 2 diabetes has met its co-primary endpoints. Yet, with the readout echoing earlier data that underwhelmed analysts, shares in…
Sanofi is paying Regeneron $1 billion upfront to collaborate on four early-stage immunology programs, teeing the longstanding partners up to try to replicate Dupixent’s success.
Eli Lilly announced its amylin-Zepbound combination eloraTZP resulted in 23.3% weight loss in adults with type 2 diabetes and obesity or overweight, topping its own triple-G drug candidate retatrutide in that population.
Base editing biotech Beam Therapeutics is suing one of its newest rivals, alleging that the upstart company stole the secrets behind one of its lead programs and used them to craft a competing therapy.
GSK is paying Wave Life Sciences $12 million upfront to take ownership of a hepatic program arising from the companies’ long-running collaboration.
Highlight Therapeutics touted positive topline results in patients with localized high-risk head and neck basal cell carcinoma (BCC).
Connect Biopharma has pointed to phase 2 data for its IL-4/IL-13 blocker as proof that the wannabe Dupixent rival can reduce respiratory attacks—although the study missed a secondary endpoint tied to a breathing test.
The FDA has granted 510(k) clearance to Miami-based VertigoDx for its portable diagnostic system that can evaluate vertigo, including benign paroxysmal positional vertigo (BPVV).
Zealand Pharma has shared primary endpoint data on Roche-partnered petrelintide, revealing that the middle dose of the amylin analog delivered the highest weight loss—9.8%—at Week 28.
Amgen has shed light on its phase 2 lupus win, revealing that its monoclonal antibody daxdilimab was tied to a 6-point reduction in disease severity at the lower dose.
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