What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort…
Background: Thyroglossal duct cyst (TGDC) is the most common congenital anterior neck mass, typically presenting in the paediatric age group as a painless midline swelling. The diagnosis is primarily clinical, supported by imaging modalities and fine needle…
Gene therapy represents a paradigm shift in modern medicine, offering potential cures for previously untreatable genetic disorders. Despite its growing clinical relevance and increasing integration into healthcare systems, knowledge of gene therapy among…
Abstract Helicobacter pylori remains a major cause of gastric diseases, while increasing antimicrobial resistance highlights the need for novel therapeutic targets. Here, we developed a comprehensive computational target-prioritization framework integrating…
The WHO Global Strategy on Diet, Physical Activity and Health recommends that the food industry provide consumers with simple, clear, and consistent food labels to support informed and healthy choices. This study aimed to (i) determine the proportion of urban…
BACKGROUND Trigeminal schwannomas are rare intracranial tumors that predominantly occur in adults and only exceptionally present in the pediatric population. Behavioral disturbances, particularly pathological laughter and impulsive dysregulation, are uncommon…
Insect herbivory triggers rapid local and systemic signaling in plants, including membrane depolarization, cytosolic Ca 2+ elevation, and activation of jasmonate-mediated defense pathways. These early events are shaped by calcium-permeable ion channels and…
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Autophagosome biogenesis depends on the coordinated action of proteins and lipids. However, how LC3B organizes at high density and contributes to autophagy-associated functions remains unclear. Using molecular dynamics simulations and super-resolution…
As infectious causes of child mortality decline, birth defects represent a growing relative proportion of neonatal and under-five deaths (as well as unmeasured morbidity) in low- and middle-income countries (LMICs), underscoring the need to integrate their…
This review synthesizes current knowledge on how animals shape plant evolution through a complex network of mutualistic and antagonistic interactions operating across ecological and evolutionary timescales. Plant–animal interactions, ranging from pollination…
Background Antimicrobial resistance (AMR) is a leading global health threat requiring coordinated surveillance across human, animal, environmental, and genomic systems. Machine learning is increasingly applied to AMR data, yet its contribution to actionable…
We read with interest the systematic review and meta-analysis by Chong et al., which showed patient-reported benefits of continuous compared with single-injection brachial plexus blocks after shoulder surgery [1]. The review is valuable because it moves the…
Abstract Mutations in the PRPF31 gene cause retinitis pigmentosa type 11 (RP11), a progressive blinding disease triggered by defects in the spliceosome, the cellular machinery responsible for RNA processing. Although gene replacement holds therapeutic promise,…
BACKGROUND: Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate…
Voltage-gated ion channels do not distribute evenly in the plasma membrane of a neuron; they localize to distinct domains where they govern the excitability of the cell and the computations it performs. Informed by electron microscopic reconstructions, models…
To maximize their reproductive success, nematodes not only must arrest their development in response to adverse growth conditions but also must quickly recover if conditions improve. However, the molecular signals that coordinate these transitions remain…
Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind,…
Protein S -sulfinylation is a reversible oxidative cysteine modification, but its contribution to acute liver injury such as those induced by acetaminophen (APAP) overdose has not been reported. Sulfiredoxin-1 (SRXN1) is the only oxidoreductase known to reduce…
Abstract GABAergic neurons critically regulate epileptic seizures, yet circuit mechanisms mediated by subtype-specific GABAergic neurons in the zona incerta (ZI) remain unclear. Here we reveal the essential role of ZI somatostatin + GABAergic neurons in…
Pituitary adenomas constitute up to 20% of primary brain tumors, yet somatic mutations are only found in 15% of pituitary adenomas. Epigenomic dysregulation has been proposed as a tumorigenic mechanism in pituitary adenomas causing Cushing’s disease (CD). We…
Chronic stress-induced osteoporosis is a prevalent yet therapeutically challenging condition, with sympathetic overactivation as a key contributor. The dominant pathological mediator and strategies for its precise, non-invasive modulation remain unclear. Here,…
Abstract ATP-dependent chromatin remodeling enzymes act together to construct complex chromatin architectures around functionally important regulatory regions like promoters and origins of replication (ORI). The INO80 complex accurately positions nucleosomes…
Vascular endothelial cells express abundant sialylated glycans, but their function remains unclear. To determine the role of endothelial overall sialylation, which is controlled by Slc35a1 , in adult mice. We generated mice with inducible deletion of Slc35a1…
Mammalian phosphatidylserine synthase-1 and -2, PSS1 and PSS2, synthesize phosphatidylserine (PS) by replacing the headgroup of either phosphatidylcholine or phosphatidylethanolamine (PE) with a serine. We determined structures of PSS2 from Equus caballus in…
PURPOSE To prospectively determine the false-negative rate (FNR) of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC). METHODS Patients with cT4 and/or cN2/N3 breast cancer with a…
Abstract Clathrin-mediated endocytosis is a major transport route for proteins from the plasma membrane to the interior of the cell. While the recruitment of cargo proteins to clathrin-coated pits is well understood, it remains an open question whether lipids…
Abstract Bacterial invasion and genotoxicity are key contributors to infectious disease progression and carcinogenesis. Yet current methods do not quantify these processes systematically and at single-cell resolution, limiting our ability to explore how…
The gradual expansion and folding of the cortex are key factors in human cognitive evolution, yet their molecular underpinnings remain not well understood. Here we identify cyclin B1 interacting protein 1 (CCNB1IP1) gene as a key regulator of human brain…
Elucidating the biological origins and biosynthetic pathways of marine natural products remains a major challenge, particularly for compounds derived from microbial consortia. Here, we identify the marine cyanobacterial genus Dapis as the source of the potent…
Maintaining a stable cerebral blood flow (CBF) despite variations in blood pressure is crucial for normal brain function. This process, called cerebral autoregulation, is often impaired in pathologies such as ischemic stroke, underlining its clinical…
Hydrogels are promising candidates for tissue repair. Non-invasive delivery of hydrogel patches involving high strains and deformations requires mechanical robustness and complex material design. Here we show chlorophyll, a sustainable plant-derived small…
SRSF3 (SRp20) is an essential RNA splicing factor. By conditional knockout (KO) of Srsf3, we found Srsf3 at its physiological level plays a tumor-suppressive role in mouse liver carcinogenesis. Srsf3 KO in hepatocytes disrupted sex disparity in the development…
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bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
Long-term cognitive outcomes following COVID-19 remain poorly characterized in South Asian populations. We assessed 181 Indian adults---99 with a reported history of COVID-19 at least six months earlier and 82 healthy controls---using standardized tests of…
Background Oral glucose tolerance test (OGTT), the gold standard for diagnosing gestational diabetes mellitus (GDM), faces significant implementation challenges, prompting interest in alternative biomarkers, such as glycated hemoglobin (HbA1c), for early…
Endosomal dysfunction is a presymptomatic hallmark of neurodegeneration. Recent evidence highlights dysregulation of endosomal pH as a central pathogenic hub in Alzheimer's disease (AD); however, the mechanisms linking pH shifts to neurodegeneration remain…
Cell division is fundamental to multicellular organisms, and stochastic partitioning of cellular components can strongly affect genome-wide gene expression. However, how cell division-associated stochasticity shapes cellular dynamics is poorly understood.…
Routine facility-based testing for hepatitis C virus (HCV) remains underutilised in India despite national screening policy. WHO has recommended HCV self-testing (HCVST) since 2021 to increase access to testing services. This study evaluated the HCVST by…
BackgroundDetermining the cause of death in electrocution is often challenging at autopsy, particularly when characteristic external electrical marks are absent. Reliable internal markers are scarce, and the neuropathological changes associated with…
Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not…
Neurotropic RNA viruses are major causes of fatal encephalitis worldwide, yet how infected neurons transition from antiviral defense to inflammatory cell death is not well characterized. Chandipura virus (CHPV), an emerging neurotropic rhabdovirus, causes…
It is important to determine whether native state dynamics drive the misfolding and oligomerization of the prion protein, which are important events in prion disease, and how they are modulated by conformational conversion. Native (N) mouse prion protein…
Triply periodic minimal surface (TPMS) architectures - Gyroid, Diamond, and Primitive - are increasingly used as delivery matrices for therapeutic agents. Although point-tracer diffusion and geodesic tortuosity (tau) describe solvent transport through their…
Objectives: To investigate whether standardising electronic healthcare record (EHR) data to the Observational Medical Outcomes Partnership (OMOP) common data model improves cross-dataset interoperability and enables transfer learning of clinical language…
Background: Guanica, Puerto Rico, has one of the highest concentrations of environmental polychlorinated biphenyls (PCBs). This PCB contamination coupled with persistent poverty, population loss, and repeated environmental disasters has taken a heavier toll on…
Background: Cardiovascular magnetic resonance (CMR) provides accurate, reproducible quantification of cardiac chamber size and function. Population-specific reference ranges, standardized categories for grading degree of deviation, and evidence for their…
Advances in transcriptomics have transformed our understanding of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease, revealing disrupted gene expression profiles and highlighting the multi-system biology of ALS. Despite major…
Cardiac and adiposity imaging-derived phenotypes (IDPs) provide quantitative measures of organ structure, function, and body composition and may reveal disease-relevant genetic variation not readily captured by heterogeneous clinical endpoints. Here, we…
Background Cardiovascular prevention is organized around target metrics. Blood pressure, LDL cholesterol, and A1c define treatment targets, quality metrics, and, implicitly, who is considered safe. Yet a value below a cutoff is a correlative measurement, not…
Coal-fired power plants remain a major source of fine particulate matter (PM2.5) exposure and mortality in the United States. Announced retirement dates mark when those burdens are expected to end, but rising electricity demand, partly from data centers…
Recent lifespan frameworks of aging theorize that pubertal development and cellular aging are governed by overlapping pathways, but the time lag between adolescence and older adulthood complicates the study of shared molecular mechanisms. Here we compare a…
Background: Endometriosis is a chronic gynecologic condition which has been linked with higher cardiovascular disease (CVD) risk. Although systemic inflammation is central to endometriosis and CVD pathophysiology, it remains unclear whether endometriosis is…
Background: Chronic obstructive pulmonary disease (COPD) is a progressive condition with high symptom burden. Advanced COPD management should relieve symptoms, optimise daily functioning and reduce carer burden, yet there is limited enactment of…
Background and Objective: For their acceptance as endpoints in clinical trials, biomarkers and clinical outcome assessment (COA) measures should show reliability by being reproducible (precise) and responsive to change. We evaluated precision and…
Background Temperature instability during neonatal transport contributes to adverse outcomes in preterm and low birth weight infants. Hypothermia in this population is associated with increased risk of intraventricular haemorrhage (IVH), sepsis, and death.…
Abstract Background: The 52-item Ontario Child Health Study Emotional Behavioural Scales (OCHS-EBS) has demonstrated reliability and validity evidence in Canadian population-based samples. This study evaluated an adapted item set of the Ontario Child Health…
Background: Diabetes poses a major global health and economic burden, and effective self management is essential for preventing complications. The National Health Service in England has recently announced plans to shift from analogue to digital services in…
Introduction: Tobacco use during pregnancy increases risks for adverse birth outcomes. In the US, tobacco use during pregnancy is associated with several poverty-related social determinants of health (fewer years of education, housing and food insecurity,…
Background. Safely managed drinking-water monitoring under Sustainable Development Goal target 6.1 uses source-water quality, yet Escherichia coli is common in household drinking water in Bangladesh despite near-universal improved sources. We compared source…
Background Studies of the 2018 United Network for Organ Sharing (UNOS) policy revision suggest improved early transplantation access for the sickest patients. It remains unknown whether these benefits vary as a function of time on the waitlist. Thus, we…
Severe cognitive decline due to dementia is an important clinical indicator signaling neurodegeneration. Predicting cognitive decline rates can be useful in establishing prognosis and modifying treatment regimens. The rate of decline is highly variable across…
Background and objectives: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease. Though neuropsychiatric symptoms (NPS) of CADASIL profoundly impact…
BACKGROUND Twin pregnancies have a two- to three-fold higher risk of preeclampsia (PE), but early prediction remains poor because current biomarkers and prediction models are largely derived from singleton pregnancies. Defining the biological changes that…
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Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out…
This study has 2 parts: First part is the main study and second part is the extension study. During the main study participants will receive 1 of 4 study medicines. If participants continue in the extension study, they will not receive any…
This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related…
The purpose of this study is to evaluate the safety and efficacy of Pumitamig in combination with chemotherapy versus Nivolumab in combination with chemotherapy in participants with previously untreated advanced or metastatic gastric,…
In this study, researchers will learn more about the use of felzartamab in participants with immunoglobulin A nephropathy (IgAN). IgAN is a kidney disease caused by the buildup of an antibody called IgA in the kidneys over time. In people…
The purpose of this study is to evaluate the efficacy of Pumitamig versus Pembrolizumab in participants with previously untreated advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%.
This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550.…
Nerandomilast is being developed to help people with systemic sclerosis by potentially improving symptoms and slowing disease progression. This study is open to adults who are at least 18 years old and have systemic sclerosis (SSc). People…
The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple…
This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new…
Primary Objective: To characterize the long-term safety and tolerability of fitusiran Secondary Objectives: * To characterize the efficacy and long-term efficacy of fitusiran as assessed by the frequency of: * Bleeding episodes *…
The purpose of this study is to evaluate the efficacy and safety of treatment with subcutaneous anifrolumab versus placebo in adult participants with systemic sclerosis. The target population for this study includes patients who meet the…
This is a phase III, randomized, double-blind, placebo-controlled, multi-center, global study to explore the efficacy and safety of volrustomig in women with high-risk LACC (FIGO 2018 stage IIIA to IVA cervical cancer) who have not…
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after…
This study aims to find out whether a study medicine called survodutide helps people control their blood sugar. Adults who live with type 2 diabetes and with a body mass index (BMI) of 23 kg/m2 or higher can join. The study has 3 parts. In…
PODOMOUNT-pFSGS This study is open to adults and adolescents with a kidney condition called focal segmental glomerulosclerosis (FSGS). The purpose of this study is to find out whether a medicine called BI 764198 helps people with FSGS.…
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the…
A study to evaluate Pumitamig versus Durvalumab following concurrent chemoradiation therapy in participants with unresectable stage III Non-small Cell Lung Cancer (NSCLC)
This is a Phase 3 global, multicenter, 52-week, open-label extension (OLE) rollover study for subjects completing study CN012-0026, CN012-0027 or CN012-0056. Subjects (randomized or non-randomized) who complete the 38-week CN012-0026 study,…
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Miricorilant in Adult Patients with Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH)
Multicenter, randomized, controlled, open-label, Phase 3 study designed to demonstrate that neladalkib (NVL-655) is superior to alectinib in prolonging progression-free survival (PFS) in patients with treatment-naïve, Anaplastic Lymphoma…
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year. Researchers want to find new drugs that relieve pain…
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar…
1. The primary goal of this clinical trial is to evaluate the pathological complete response (pCR) rate of oral paclitaxel solution combined with subcutaneous pertuzumab and trastuzumab in the neoadjuvant treatment of early or locally…
Background: High-grade neuroendocrine carcinomas (HGNEC) are cancers that develop in different parts of the body, including the digestive tract, genitals, neck, and head. One drug (belinostat), combined with 2 other drugs (etoposide and…
This study is open to adults with extensive-stage small cell lung cancer. The purpose of this study is to find out how well people with this type of cancer tolerate taking study medicines called obrixtamig and pumitamig. Another purpose is…
This phase I/II trial studies the side effects of pembrolizumab and romidepsin and to see how well they work in treating participants with peripheral T-cell lymphoma that has come back or that does not respond to treatment. Immunotherapy…
Multi-center, double-blind, placebo-controlled, parallel group design. Patients with myocarditis will be screened and, if eligible, randomized within 10 days of the diagnostic CMR to CardiolRx or placebo. CardiolRx is pharmaceutically…
Background: Prostate cancer is the second most common cause of cancer-related death among men in the United States. Early-stage, low-grade prostate cancer is managed with active monitoring. However, 35% of men with this cancer will need…
This is an open-label, multi-site study of AR Blockade with carotuximab in patients who have progressed on androgen receptor signaling inhibitor (ARSI) therapy. This study will begin with a safety assessment in the first 10 subjects (part…
The goal of this study is to learn about the safety of alimatravir (MK-8527) in transgender and gender-diverse people and if they tolerate it.
In patients with a limited oligometastatic burden (cancer has spread but is not yet considered metastatic), emerging evidence suggests that treatment of all sites of disease with ablative therapies can improve patient outcomes, including…
The purpose of this study is to learn about the safety and effects of giving vepdegestrant along with PF-07220060. Vepdegestrant is studied to see if it can be a possible treatment for advanced metastatic breast cancer. This type of cancer…
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or urethra, but require an additional treatment called immunotherapy to help prevent their urinary tract (urothelial) cancer…
This phase II trial tests how well gemcitabine, cisplatin and nab-paclitaxel given before surgery (neoadjuvant) works in treating patients with pancreatic cancer that can be removed by surgery (resectable) or that is borderline resectable.…
This Phase II, open-label, multicenter study will evaluate the safety, efficacy, and pharmacokinetics of glofitamab in combination with rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in…
The main objective of this study is to evaluate the efficacy of different dose levels of NBIP-01435 on reducing elevated androstenedione (A4) levels in adults with classic CAH.
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma.…
This is an open-label, multicenter, non-randomized extension study. Participants receiving atezolizumab monotherapy or atezolizumab combined with other agent(s) or comparator agent(s) in a Genentech or Roche-sponsored study (the parent…
CAR-T cell therapy targeting CD19 has been shown to be effective in heavily-pretreated B-cell ALL or NHL, but relapses post-CAR-T are common, and CD19 antigen loss is one of the reasons. Thus, the investigators supposed that CD19/CD22…
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Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
At the White House on Wednesday, Essar Group co-founder Ravi Ruia announced an $18 billion investment to build America’s largest steel plant in Iowa.
The Department of Pharmaceuticals has approved 41 projects worth around Rs 1,600 crore in financial assistance under the first call of the Promotion of Research and Innovation in Pharma MedTech Sector scheme. The…
Pediatric healthcare startup Primerry has raised INR 7.1 crore (approximately $760,000) in a pre-seed funding round to strengthen product development, expand clinical expertise, and build distribution across India.…
SAMMMM is a growing self-care brand, targeting Gen Z and Gen Alpha consumers. Launched in 2005, it was co-founded by a father-daughter duo.
UT administrator Gulab Chand Kataria has sought ₹2,000 crore from the Centre for the proposed Chandigarh Regional Medical Hub and 36 additional postgraduate medical seats for the city’s medical college, as part of…
The manufacturing facility adds 135 million-unit annual capacity, with Carbapenem line now operational and validated under Biodeal’s ownership The post Biodeal Pharmaceuticals acquires Biological E facility, expands into…
ITC has acquired the remaining 52.5% stake in Sproutlife Foods for ₹645 crore, bringing its total investment to around ₹900 crore. The move aligns with ITC's strategy to enhance its FMCG portfolio, as Sproutlife's…
Linux is a specialty-focused domestic formulations platform with a portfolio of over 125 brands spanning ~400 SKUs. The post Linux secures USD 70mn strategic investment from ChrysCapital and Tata Capital Healthcare Fund…
The agreement is expected to add South Africa to Elitecon’s international network and create additional employment at its Nashik plant.
Private hospitals treating patients under Rajasthan’s Mukhyamantri Ayushman Arogya Yojana (MAA Yojana) will have to upload photographs of patients admitted to intensive care units (ICUs) along with their treating doctors…
Lab informatics is changing how pharma companies transfer knowledge, control quality and move from development to commercial manufacturing, writes Swati Rana The post When the lab talks to the plant appeared first on…
The acquisition marks Zenex's third strategic acquisition since partnering with Multiples and represents another significant milestone in its journey The post Zenex Animal Health complete acquisition of Sava Healthcare…
Indian healthcare stocks eroded 248 billion rupees ($2.6 billion) in market value on concerns that high-margin pharmacy revenue may come under threat after the top court questioned steep markups on lifesaving cancer…
Andhra Pradesh government has earmarked ₹34 crore to establish three new cath labs in Tirupati, Nellore and Srikakulam government teaching hospitals. This is part of the plan to strengthen cardiac care services in public…
“This is carnage,” the Supreme Court said while voicing its concern over a steep markup of ten times on cancer drugs by hospitals and batted for a uniform 16 per cent margin on all medicines. A bench of Justices Vikram…
India’s rise as a medical tourism hub known for its advanced, affordable and trustworthy medical care offers valuable lessons for emerging African economies. Many African countries are looking to explore how India…
Union Minister for Health & Family Welfare, J.P. Nadda, addressed the World Congress of Gastroenterology (WCOG 2026) in New Delhi. Being held in India for the first time, the four-day international Congress commenced…
Apollo TeleHealth has welcomed the BRICS New Delhi Declaration’s focus on digital healthcare and artificial intelligence, saying the priorities could help extend access to care in underserved areas. Adopted at the BRICS…
Addressing the World Congress of Gastroenterology (WCOG 2026) here, Nadda termed screening for non-communicable diseases (NCDs) an important part of preventive healthcare.
Karnataka’s Government First initiative will give 100 startups up to Rs 25 lakh each to pilot and validate solutions with government departments.
MSP for wheat now stands at ₹2,610 per quintal against ₹2,585 per quintal announced for 2026-27 marketing season (April-March)
Six B-school teams, chosen from 4,429, pitch CM Fadnavis ideas to make Maharashtra an innovation hub by 2035 at TGC 2026 today.
A media report said Venu Srinivasan has asked the Maharashtra Charity Commissioner to inquire into the governance of two Tata Trusts and their role in Tata Sons, amid an ongoing tussle between the two entities.
Sri Harsha Chakrapani, Pharmaceutical Process Engineer and Independent Researcher highlights the need for pharma manufacturers to move from batch-based validation to a lifecycle approach, with continued process…
The sell-off came after the Supreme Court raised concerns over the wide gap between the price at which hospitals procure medicines and the maximum retail price charged to patients.
Merck & Co. touted a win for its anti-TL1A antibody in a phase 2b trial in patients with moderate to severe hidradenitis suppurativa (HS).
The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.
ai3Bio has emerged from stealth with $48 million in funding and a buzzing platform for targeting T cells in autoimmune disease.
Novo’s ongoing efforts to rejuvenate its pipeline have seen the Big Pharma turn to one of the most in-demand drug developers in China.
AstraZeneca is investing $2 billion in Summit Therapeutics to accelerate the development of PD-1xVEGF bispecific ivonescimab in combination with antibody-drug conjugates (ADCs). The newly minted partners will start by…
Precision Neurosciences, which specializes in brain-computer interface technology, raised $250 million in an oversubscribed Series D financing round.<br>
Sofinnova Partners has hauled in 82 million euro ($93.3 million) in an oversubscribed financing round. The European venture capital group said it will use the cash to expand its medtech creation strategy in Europe and…
Life sciences and technology companies supported by the OBIO's CAAP have collectively raised more than $1bn in capital.
Novo forges this deal as the company looks to extend the lead secured from its first-to-market advantage in the oral weight loss drug arena.
AstraZeneca has agreed to invest $2bn in newly issued equity in Summit Therapeutics to develop combination therapies using the bispecific antibody ivonescimab and ADCs across multiple tumour types.
Tolerance Bio has signed an agreement securing an exclusive licence from Tanabe Pharma for TLB-33 in a deal of up to around $560m.
As always, if you know of layoffs occurring at a biotech, please reach out to the Fierce Biotech editorial team.
Eli Lilly announced its amylin-Zepbound combination eloraTZP resulted in 23.3% weight loss in adults with type 2 diabetes and obesity or overweight, topping its own triple-G drug candidate retatrutide in that population.
Base editing biotech Beam Therapeutics is suing one of its newest rivals, alleging that the upstart company stole the secrets behind one of its lead programs and used them to craft a competing therapy.
GSK is paying Wave Life Sciences $12 million upfront to take ownership of a hepatic program arising from the companies’ long-running collaboration.
Highlight Therapeutics touted positive topline results in patients with localized high-risk head and neck basal cell carcinoma (BCC).
Connect Biopharma has pointed to phase 2 data for its IL-4/IL-13 blocker as proof that the wannabe Dupixent rival can reduce respiratory attacks—although the study missed a secondary endpoint tied to a breathing test.
The FDA has granted 510(k) clearance to Miami-based VertigoDx for its portable diagnostic system that can evaluate vertigo, including benign paroxysmal positional vertigo (BPVV).
Zealand Pharma has shared primary endpoint data on Roche-partnered petrelintide, revealing that the middle dose of the amylin analog delivered the highest weight loss—9.8%—at Week 28.
Amgen has shed light on its phase 2 lupus win, revealing that its monoclonal antibody daxdilimab was tied to a 6-point reduction in disease severity at the lower dose.
Eli Lilly has shared detailed data from a phase 3 retatrutide trial, revealing that more than one-third of patients on the top dose of the triple-G drug candidate lost at least 25% of their body weight.
A newly launched $5 million clinical trial program allows clinical trial sponsors to start trials in as little as 45 days in Ontario.
As antiviral specialist Enanta Pharmaceuticals endeavors to expand into immunology, the company has decided to lay off 37 employees, Fierce has learned.
uniQure’s Huntington’s disease gene therapy has failed to significantly slow disease progression after 48 months, sending the biotech’s stock down 41% when trading began. But mitigating circumstances and the ongoing…
Roche has slammed the brakes on an obesity antibody after the candidate showed little hope of hitting its endpoints in a phase 2 study.
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