What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
BACKGROUND: Neural mobilization has increasingly been incorporated into physiotherapy management for cervicogenic headache (CGH); however, evidence regarding its clinical effectiveness remains limited. This scoping review aimed to explore and map the existing…
Participatory Rural Appraisal (PRA) is a field-based approach used to gather data or gain insights into the conditions and realities of rural communities. The methods and tools employed in PRA are chosen based on the specific type of data needed. It is a…
Precise 3D segmentation of brain tumors based on multi-modal magnetic resonance images(MRI) is challenging due to intensity heterogeneity within tumor sub-regions, irregular tumor boundaries, extreme unbalanced class distribution at the voxel level and…
Colocasia boyceana Gogoi & Borah was described from state of Arunachal Pradesh, India. During the present study, the species was collected from Assam for the first time, growing in Jatinga area of Dima Hasao district of Assam. A detailed morphological…
Seagrasses have gathered increasing attention due to their multifaceted ecological roles. Apart from their ecological significance, seagrasses have exhibited potent antifungal properties, indicating potential for diverse applications. The antifungal efficacy…
Cultivated wheat has a narrow genetic base; therefore, wild relatives represent an invaluable source of novel alleles for broadening genetic diversity and enhancing yield potential. We evaluated 109 wheat–Aegilops derivatives including parents and three check…
KAU Manu Ratna is a rice variety popular for its short duration and high yield. In the present study, the gene action of flowering genes of KAU Manu Ratna was studied in breeding populations obtained by crossing it with a long duration variety Swarna-Sub1.…
Rice (Oryza sativa L.) is a major staple crop, and simultaneous improvement of yield, grain quality, and stress resistance is essential under changing climatic conditions. However, comprehensive diversity analyses that integrate agronomic, quality, and stress…
Abstract Immune checkpoint inhibitors (ICIs) have transformed treatment for non-small cell lung cancer (NSCLC), but resistance to these therapies is common. We report here results from a phase I trial combining intratumoral injection of a CCL21-expressing…
Abstract Long-acting drug–Fc conjugate (CD388) has emerged as a new class of antivirals against influenza A and B, yet the mechanisms governing how Fc conjugation reshapes small-molecule function remain undefined. Here we establish a programmable multivalent…
Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile , elevated c-di-GMP levels inhibit sporulation, but the…
Primates constitute one of the most phylogenetically and ecologically diverse eutherian mammalian orders and have a central role in advancing our knowledge of human evolution, speciation processes, and conservation biology. Although thousands of whole-genome…
The tumor suppressor RAD51D is essential for homologous recombination (HR). Pathogenic variants in RAD51D are associated with breast and ovarian cancers. However, most clinical missense variants are of uncertain significance. Here, we report a multiplex assay…
Peptide macrocyclization is a powerful strategy to enhance the stability, rigidity, binding affinity, and cellular permeability of therapeutic candidates. Peptide bicycles provide superior conformational constraint but remain difficult to generate in…
Slow inactivation in voltage-gated sodium channels (Navs) is crucial for regulating cell excitability. Many studies indicate that the selectivity filter (SF) serves as the inactivation gate, but the structural mechanism and coupling between the distal primary…
Abstract Understanding how chromatin’s physicochemical properties shape its emergent organization is central to deciphering genome function. To address this, we present OpenCGChromatin, a high-performance coarse-grained model that achieves near-atomistic…
DCAF7 is one of the few DCAFs expressed in hematopoietic stem cells (HSCs). Using a conditional knockout mouse model, we discovered that the absence of DCAF7 leads to accumulation of differentiating progenitors in the bone marrow, and impairs self-renewal…
Abstract Speech processing involves a hierarchy of cognitive layers from low-level phonetic to high-level semantic representations. However, interactions are not only feed-forward; feedback mechanisms are crucial for real-time, accurate speech recognition. Yet…
Although increasing evidence implicates subchondral bone alterations in osteoarthritis, the spatial organization of subchondral bone remodeling remains unclear. Applying spatial transcriptomics to human subchondral bone, we identify a spatially conserved…
Triple-negative breast cancer (TNBC) develops in hypoxic, nutrient-limited tumors enriched with macrophages and cell death. We show that metabolically distinct TNBCs differentially exploit macrophage-derived nutrients, influencing tumor growth and therapeutic…
High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in…
Immune protection against infection is often treated as a fixed property of a person’s immune response. But infection risk also depends on the number of infectious contacts a person experiences, which generally increases as community transmission rises. This…
Despite substantial treatment improvements, the 5-year survival rate for metastatic osteosarcoma (OS) is still as low as 20%. Immunocompetent genetic mouse models of OS have been introduced, enabling in vivo OS studies. Here, we present the ROCCIA mouse, a…
Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using…
Abstract Despite loss of responsiveness to exogenous leptin in obesity, endogenous leptin continues to restrain feeding, although the neural substrates that remain sensitive and mediate this effect remain unknown. Combining spatial transcriptomics with…
Post-transcriptional transfer RNA (tRNA) modifications dynamically regulate translational capacity, yet whether the tRNA epitranscriptome is temporally coordinated with gene expression programs during bacterial growth remains unknown. Here, we combine…
Most pediatric acute myeloid leukemia (pAML) patients achieve complete remission after chemotherapy, yet nearly 40% ultimately relapse and die from their disease. High risk cases are typically referred for stem cell transplantation (SCT) in first remission,…
Cryptovivipary and vivipary, referred to as (crypto)vivipary, occur across multiple angiosperm lineages and enable embryos to continue developing before dispersal. Yet, this trait raises a fundamental question: how are seed-specific abscisic acid (ABA)…
Nothing in this stream matches those filters.
bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
The authors have withdrawn this manuscript because some authors have raised a conflict-of-interest concern that was identified belatedly. A new version will be submitted. Therefore, the authors do not wish this work to be cited as reference for the project. If…
At the nucleosome scale, chromatin is an actively remodeled polymeric system whose organization is continuously reshaped by ATP-dependent remodelers that slide, evict, and reassemble nucleosomes along DNA. However, how the local structural rearrangements…
We present SOP-Multi-{pi}, an enhanced version of the two-bead-per-amino-acid resolution Self-Organized Polymer (SOP) model designed to investigate the conformational dynamics of Intrinsically Disordered Proteins (IDPs) and their phase behavior in biomolecular…
Social factors are consequences and determinants of chronic pain, yet little is known about how informal social support operates for people with chronic pain and HIV. The overlapping burdens of emotional distress and chronic pain in people living with HIV…
Objective: To evaluate whether the well-established age-related reduction in antral follicle counts (AFC) is greater among women with higher concentrations of endocrine-disrupting chemicals. Design: Prospective cohort study using the doubly robust (DR)…
The author has withdrawn this preprint because a check of the manuscript against the simulation code that produced its results found that parts of the Methods and Supporting Information do not accurately describe that code, and that several survivorship…
Despite the widespread use of L-type calcium channel blockers (CCBs), recent observational and murine functional work has suggested a potential adverse effect of this medication class on the aorta. Here, we apply a Mendelian randomization (MR) framework to…
Importance: With emerging gene-targeted therapies in amyotrophic lateral sclerosis (ALS), gene discoveries and genetic diagnoses provide a crucial path to treatment. Pathogenic variants with moderate effect or incomplete penetrance, however, remain…
Background: Common variable immunodeficiency is frequently underrecognized due to its heterogeneous clinical presentation, resulting in diagnostic delays that increase disease-related complications, with each year of delay increasing mortality risk by 4% for…
Objective: To critically evaluate the influence of extracellular matrix stiffness on tumor progression, prognosis, and clinical implications in patients with oral squamous cell carcinoma. Design: This systematic review followed the PRISMA (Preferred Reporting…
The multistage model of carcinogenesis explains the steep rise of cancer incidence with age through accumulated events, and reliability theory extends this principle to systems whose failure requires several components. We asked whether the same idea could…
Importance. Anorexia nervosa (AN) is a severe metabo-psychiatric disorder with heterogeneous outcomes and elevated mortality. Characterizing severity trajectories may improve early risk stratification and targeted intervention. Objective. To identify AN…
Background and Hypothesis Identifying which patients with schizophrenia will remain stable and which will relapse is relevant to both trial design and clinical practice. We hypothesized that higher negative and lower positive symptoms at baseline would predict…
Background: Systematic reviews are critical for informing evidence-based medicine, policy, and future research. However, conducting a systematic review is labour- and cost-intensive and error-prone. Elicit is an AI tool that claims to replicate the systematic…
Objectives: To determine whether distinct anxiety phenotypes (rumination, global anxiety and worry; RAW) are associated with plasma brain-derived (BD) phosphorylated-tau (p-tau) biomarkers of Alzheimer's disease (AD) in older adults. Design: Cross-sectional…
Background: The decline of mental health among adolescents in the UK over the past two decades has occurred amidst many societal and technological changes making it difficult to identify drivers of these trends. We aimed to identify which aspect of life showed…
Introduction In July 2025, WHO launched the 3 by 35 Initiative calling on countries to increase real prices of tobacco, alcohol, and sugary drinks by at least 50% by 2035 to secure an additional $ 1 trillion in public revenue. While the effectiveness of excise…
Background: Early pandemic responses must balance transmission control against socioeconomic costs but the strategy that minimises total costs and whether it varies by country remain unknown. We analysed country-specific cost-optimal intervention strategies…
To compare virtual noncontrast (VNC) error between deep-silicon photon-counting CT (PCCT) and dual-energy energy-integrating detector CT (EID-CT) in a matched phantom and characterize tissue-specific error in humans. This prospective exploratory study included…
Background: Accurate patient understanding of lung cancer screening (LCS) results is critical for engagement and follow-up adherence, given the currently low screening uptake. While artificial intelligence (AI) systems show promise in facilitating patient…
Deep-silicon photon-counting CT uses a detector architecture distinct from cadmium-telluride systems and has not been evaluated for pediatric head imaging. To compare attenuation-dependent performance of deep-silicon photon-counting CT (dSi-PCCT) with…
Aims: Our primary aim was to determine the immediate effects of using a supported stepping device on the real-time locomotor behavior of pre-walking infants with Down syndrome (DS). Our secondary aim was to characterize the role of the caregiver in…
Background: Safely walking through complex environments requires the use of visual information to plan and regulate steps, while managing competing cognitive demands. Age-related changes in visual control of gait and executive function may contribute to unsafe…
Introduction Maintaining long-term positive airway pressure (CPAP) adherence is a major challenge when treating obstructive sleep apnea (OSA). We evaluated factors associated with one-year CPAP adherence and developed models predicting Month-12 adherence and…
Seasonal flooding in Adamawa State, Nigeria damages health facilities, breaks supply chains, and displaces health workers and communities, while increasing health needs. Sexual and reproductive health (SRH) services are often deprioritized, yet evidence on how…
Introduction Mechanical thrombectomy has been well-established as the standard of care treatment for patients with moderate to severe acute ischaemic stroke secondary to large vessel occlusion. However, the clinical value of endovascular treatment (EVT) in…
Background & Aims Personalized nutrition has the potential to improve nutritional intake and clinical outcomes in hospitalized patients by adapting to individual dietary needs and preferences. Despite its promise, no personalized nutrition product (PNP) for…
Study question: Are maternal age and a history of previous pregnancy losses associated with the timing of pregnancy loss for women undergoing ART treatment? Summary answer: Among women who underwent ART treatment, younger women had a higher risk of very early…
Background. Glioma surgery requires balancing maximal tumor resection against preservation of neurological and cognitive function. Intraoperative direct electrical stimulation guides this balance but is invasive and not always feasible. Preoperative…
Purpose Tarlatamab, a bispecific T-cell engager, has generated favorable response and survival outcomes in relapsed small cell lung cancer (SCLC). Factors influencing tarlatamab-associated treatment outcomes and toxicity have yet to be established. We…
Nothing in this stream matches those filters.
Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
CKJX839D12303 is a research study to determine if the study treatment, called inclisiran, in comparison to placebo taken in addition to statin medication can effectively reduce the total amount of plaque formed in the heart's vessels as…
This is a study evaluating the efficacy and safety of calderasib with pembrolizumab as first-line treatment in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) with identified Kirsten rat sarcoma viral…
The purpose of this study is to evaluate the long-term safety and tolerability, of open label iptacopan in primary IgA nephropathy participants who have completed either the CLNP023X2203 or CLNP023A2301 clinical trials. The open-label…
A5409/RAD-TB is an adaptive Phase 2 randomized, controlled, open-label, dose-ranging, platform protocol to evaluate the safety and efficacy of multidrug regimens for the treatment of adults with drug-susceptible pulmonary tuberculosis (TB).…
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the…
The study will assess the efficacy and safety of pegozafermin administered in participants with compensated cirrhosis due to MASH (biopsy-confirmed fibrosis stage F4 MASH \[previously known as nonalcoholic steatohepatitis, NASH\]).
CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the…
The study will assess the efficacy and safety of 2 dose regimens of pegozafermin compared to placebo for the treatment of liver fibrosis stage F2 or F3 in adult participants with MASH.
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome…
This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative…
The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia…
This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.
The purpose of this study is to provide continued access to anifrolumab to eligible participants who are continuing to derive clinical benefit from treatment at the end of a parent clinical study, as assessed by the Investigator, while…
Triple-negative breast cancer is a subtype of breast cancer that is clinically negative for expression of estrogen and progesterone receptors (ER/PR) and HER2 protein. It is characterized by its unique molecular profile, aggressive…
Voltage Gated Sodium Channels Over the years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage gated sodium channels (VGSC) expressed in non-nervous or non-muscular organs are often…
This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal…
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is…
The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival…
Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with…
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants with PPF over 52 weeks.
Bundibugyo virus (BDBV) causes severe and often fatal outbreaks of Bundibugyo virus disease (BVD). No vaccine against BDBV is licensed. There is an urgent need to identify vaccines that are safe, immunogenic, and effective in preventing…
The study is designed to evaluate the safety, efficacy, and pharmacokinetics (PK) of two doses of AMT-143 in participants after unilateral bunionectomy.
The goal of this clinical trial is to determine whether a selected population of women with early-stage, low-risk breast cancer can avoid hormone therapy without increasing their risk of relapse. It will also evaluate the prognosis of these…
This is a Phase 2b, randomized, double-blind, placebo-controlled, multiple ascending dose study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of TE-8105 in adults with overweight or obesity, with or…
A multicentre single arm phase II trial assessing the efficacy of immunotherapy, chemotherapy plus stereotactic radiotherapy to metastases followed by definitive surgery or radiotherapy to the locoregional primary tumour, in patients with…
The researchers are doing this study to find out whether PK-targeted fludarabine is an effective Lymphodepletion (LD) chemotherapy approach for people with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) who will receive…
This study aims to determine the safety, pharmacokinetics (PK) and recommended Phase 3 dose (RP3D) of RYZ101 in Part 1, and the safety, efficacy, and PK of RYZ101 compared with investigator-selected standard of care (SoC) therapy in Part 2…
This clinical trial tests how well dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with standard clinical evaluation works to assess treatment response for patients with pancreatic cancer that may be able to be removed by…
Study consists of two main parts to explore tacabrutideg recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy safety expansion of selected doses, and a Phase 2 (expansion cohorts)
This is a phase 2 study to evaluate the efficacy and safety of foscenvivint in patients with liver cirrhosis resulting from HIV/HCV co-infection in the setting of hemophilia.
The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity or overweight. Trial 20250197 is an extension of trial 20210181 (NCT06858839).
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective. Researchers want to know if…
The goal of this clinical trial is to learn if the IV Iron treatment ferric derisomaltose helps in the treatment of chronic heart failure in people with iron deficiency. The main question it aims to answer is: • How many participants are…
In patients with prostate cancer (PC), cardiovascular disease (CVD) causes significant morbidity and is the second leading cause of death. Both pre-existing CVD and the use of androgen deprivation therapy (ADT)-a key cornerstone of…
This phase I/II trial studies the side effects and best dose of ABBV-383 and to see how well it works in treating patients with Waldenström macroglobulinemia that has come back after a period of improvement (relapsed) or that does not…
The purpose of this study is to find out whether BMS986365 in combination with degarelix, given before standard surgical treatment (radical prostatectomy), is a safe and effective treatment that causes few or mild side effects for people…
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than three months.…
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic neuropathy-Plus…
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-small cell lung cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study…
Nothing in this stream matches those filters.
Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
The company is likely to be valued ₹1,800-2,000 crore, the people said. KPMG is advising the promoters on the stake sale. BL Lifesciences, a fourth-generation family-owned business, primarily focuses on products for…
Farmers are digging wells and planning drip irrigation as prolonged heat and lack of moisture begin affecting saffron corms
Formoflo-G MDI combines Glycopyrronium Bromide, Formoterol Fumarate and Fluticasone Propionate for the management and treatment of moderate to severe COPD The post Lupin launches triple-combination MDI for COPD in India…
The New Employees Health Scheme (NEHS), meant for government employees, pensioners and their eligible family members, has covered 919 hospitals— 778 private and 141 state-run — and approved cashless treatment for 15,395…
The Qatari Businessmen Association (QBA) is keen to expand its relationships with economic institutions and business communities in the US, and to open direct channels between Qatari investors and American companies. QBA…
Riociguat Tablets are approved by the USFDA as a generic equivalent of Adempas Tablets in five strengths The post Zydus, MSN launch generic riociguat in US appeared first on Express Pharma .
Glenmark’s Adapalene Gel USP, 0.1% can be compared to the active ingredient of Differin Gel, 0.1% The post Glenmark launches Adapalene Gel USP 0.1% in new pump packs in US appeared first on Express Pharma .
Bay of Bengal expected to swing to easterlies as an approaching wave sets up the transition; north-east monsoon could arrive in next 10 days around normal time, suggest models
A Mumbai business consultant found out this year what increasingly divides Indian healthcare: not whether a hospital can perform an advanced procedure, but who pays for it afterward. She had bought a state-run health…
The Keralam government is planning to bring in a legislation to regulate treatment costs in private hospitals, Health Minister K Muraleedharan said on Thursday. The government will constitute a four-member committee…
India’s apex body for healthcare quality assessment and accreditation, the National Accreditation Board for Hospitals & Healthcare (NABH) under the Quality Council of India(QCI), has appointed Dr Parag R. Rindani as…
Delhi-NCR’s rise as India’s leading robotic surgery hub is not simply a story about hospitals acquiring expensive machines. It is also a story about how advanced medical capacity is concentrating in a major urban region,…
The Chhattisgarh Government has announced plans to develop a 200-acre Medicity and a 141-acre Pharma Park in Naya Raipur aimed at strenghtening integrated health and life sciences ecosystem, The initiative is…
India’s apex medical education regulator received 360 complaints of doctors’ misconduct since 2023 and rejected appeals in more than half of these cases. Responding to a Tribune query under the Right to Information Act,…
The United States faces a projected shortage of more than 141,000 physicians by 2038, raising concerns about access to routine care and the healthcare system’s ability to respond to major emergencies. Federal workforce…
Ventilators worth crores of rupees, supplied to a hospital in Uttar Pradesh’s Maharajganj during the Covid-19 pandemic, have remained unused for years due to a lack of the infrastructure and resources needed to operate…
In response to a laboratory worker's suspected death from bubonic plague, Russian officials have enforced quarantine protocols. Approximately 200 individuals are under watch for potential exposure to the infection, which…
Soi's comments come against the backdrop of Maharashtra scrutinising steep markups on hospital consumables and the Supreme Court's recent observation on a cancer drug carrying a markup of 10 times with patients required…
Proteins are important diagnostic targets because they are involved in almost every biological process; over the last two decades, scientists have developed aptamers for hundreds of disease-relevant proteins and have…
Gujarat government extends registration deadline for groundnut, moong, soybean and urad
Experts seek wider cocoa cultivation backed by quality planting material and certification
Skin Beyond Borders announced its audited skincare marketplace in August. What industry gap are you trying to address? My experience in the industry spans around 20 years. I formally started working in dermatology in…
The open letter from nine EU pharma leaders and China’s new five year pharma plan are the latest and clearest signals that the stakes are only getting higher The post Does India Pharma Inc need a new blueprint? appeared…
The findings, published in The Journal of the American Medical Association (JAMA) Network Open, also showed that the link between daily step count and mental health continued up to 12,000 or more steps a day, with no…
Kusum Healthcare says its manufacturing facility in Sumy, Ukraine, was hit by a Russian drone attack, with one employee confirmed dead and several others injured. The post Kusum Healthcare facility in Ukraine hit by…
When Xaira Therapeutics first debuted in 2024 with a gobsmacking $1 billion in funding, a natural expectation would have been for a flurry of further activity to follow. Instead, the buzzy AI biotech went quiet.
Novartis is paying Abogen Biosciences $575 million upfront for an mRNA-encoded T-cell engager that showed early clinical promise in autoimmune disease. The deal, which includes up to $7.2 billion in milestones, comes…
Bayer has announced plans to invest $2.2bn in a new pharmaceutical manufacturing facility in Ohio, US.
Unlike other therapies in this class, Abogen’s ABO2203 is designed to produce a T-cell engager protein in vivo through an mRNA-encoded system.
Varda secures this capital as drugmakers tout the potential of manufacturing in microgravity conditions to create differentiated medicines.
Genentech is paying Alector $100 million upfront for exclusive rights to a preclinical drug candidate that targets a driver of neurodegeneration in Parkinson’s disease.
Vaxcyte has seen its stock jump after the biotech’s 31-valent pneumococcal vaccine candidate went head-to-head with Pfizer’s Prevnar 20 and Merck & Co.’s Capvaxive in a phase 3 contest.
Why Your Operating Model Should Reflect Your Company’s DNA
Choosing a biologics CDMO goes beyond capabilities. Four criteria can help sponsors assess quality, cost, technology and long-term partnership.
Eli Lilly has been pushing at an open door by tacking on $870 million in biobucks to its existing collaboration with Gate Bioscience.
The 2026 Nobel Prize in Physiology or Medicine has been awarded to three scientists who forged a new neuroscience technique that uses light to precisely flip chosen neurons on and off.
Click Therapeutics has nabbed FDA approval for its digital therapeutic Motivista, which now becomes the first authorized treatment for negative schizophrenia symptoms.
Genmab has linked an antibody-drug conjugate to a median progression-free survival of 9.5 months, leading TD Cowen analysts to hail the asset as “clearly superior” to AbbVie’s Elahere.
Australia’s CSL is paying $355 million upfront for the rights to Alentis Therapeutics’ phase 2-stage fibrosis drug.
The FDA has approved a surgically implanted pulmonary heart valve for pediatric patients with congenital pulmonary valve disease.
Eric Cantor, who represented Virginia in the U.S. House of Representatives for 14 years and served as House majority leader from 2011 to 2014, will step up as PhRMA’s next president and CEO on Nov. 9. Plus, Bayer has a…
Adecto Pharmaceuticals’ 12-year story has come to an end as the immunotherapy biotech blamed a “risk-averse funding environment” for shutting up shop.
Abbott is kick-starting the U.S. commercial launch of SimpleScreen CRC, an FDA-approved blood-based colorectal cancer (CRC) screening test for adults age 45 and older who are at average risk for the disease.
As always, if you know of layoffs occurring at a biotech, please reach out to the Fierce Biotech editorial team.
The revelation of a patient death in Bristol Myers Squibb’s phase 3 trial of a potential pulmonary fibrosis treatment has raised concerns ahead of the study’s readout, but analysts were quick to dispel worries about…
Roche Diagnostics has launched a new in vitro diagnostic test for newborn screening to detect a series of rare disorders.
A more subdued volume of biopharma layoffs continued into the third quarter of 2026, validating predictions that the sector has moved beyond the avalanche of redundancies experienced last year.
Foghorn Therapeutics is laying off 40% of its workforce after a long-running collaboration with Eli Lilly collapsed over disappointing phase 1 data.
When recombinant DNA pioneer Herbert Boyer, Ph.D., first got a call from venture capitalist Robert Swanson about starting a company, the savvy scientist wasn’t sure a meeting would be worth his time.
A phase 3 trial of Boehringer Ingelheim’s survodutide in people with obesity and Type 2 diabetes has met its co-primary endpoints. Yet, with the readout echoing earlier data that underwhelmed analysts, shares in…
Nothing in this stream matches those filters.