What's new in bioscience: research, preprints, clinical trials, funding and company moves. Global, with an India filter. Nothing here is hand-picked. The site collects and sorts itself, every day.
Updated · 160 items
Peer-reviewed papers. Global items come only from a whitelist of 46 core journals. A new paper has no citations yet, so where it published is the only quality signal available on the day it appears. India-affiliated work uses a wider net, because the local ecosystem mostly does not publish in Nature.
BACKGROUND: Neural mobilization has increasingly been incorporated into physiotherapy management for cervicogenic headache (CGH); however, evidence regarding its clinical effectiveness remains limited. This scoping review aimed to explore and map the existing…
Accounting for approximately 20% of all childhood central nervous system (CNS) malignancies, medulloblastoma is the most common malignant pediatric brain tumor. Current standard-of-care treatment, comprising craniospinal irradiation, adjuvant chemotherapy, and…
Information and communication technologies (ICTs) are increasingly used in agricultural extension to improve access to timely and relevant information. This study assessed the attitudes of key stakeholders towards ICT use in Punjab’s agricultural extension…
The intensification of environmental stressors due to climate change has positioned the Cactaceae family as a vital frontier in sustainable, climate-resilient agriculture. These plants rely on Crassulacean Acid Metabolism (CAM), which confers exceptional…
Conservation agriculture (CA) has emerged as a promising approach for enhancing agricultural sustainability by improving soil health, resource use efficiency, climate resilience, and environmental quality. However, the performance of CA in India remains highly…
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal hypersensitivity reaction characterized by rash, fever, hematological abnormalities, lymphadenopathy, and multi-organ involvement. Non-steroidal anti-inflammatory drug-induced…
Abstract Immune checkpoint inhibitors (ICIs) have transformed treatment for non-small cell lung cancer (NSCLC), but resistance to these therapies is common. We report here results from a phase I trial combining intratumoral injection of a CCL21-expressing…
Abstract Long-acting drug–Fc conjugate (CD388) has emerged as a new class of antivirals against influenza A and B, yet the mechanisms governing how Fc conjugation reshapes small-molecule function remain undefined. Here we establish a programmable multivalent…
Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile , elevated c-di-GMP levels inhibit sporulation, but the…
Primates constitute one of the most phylogenetically and ecologically diverse eutherian mammalian orders and have a central role in advancing our knowledge of human evolution, speciation processes, and conservation biology. Although thousands of whole-genome…
Peptide macrocyclization is a powerful strategy to enhance the stability, rigidity, binding affinity, and cellular permeability of therapeutic candidates. Peptide bicycles provide superior conformational constraint but remain difficult to generate in…
Slow inactivation in voltage-gated sodium channels (Navs) is crucial for regulating cell excitability. Many studies indicate that the selectivity filter (SF) serves as the inactivation gate, but the structural mechanism and coupling between the distal primary…
Abstract Understanding how chromatin’s physicochemical properties shape its emergent organization is central to deciphering genome function. To address this, we present OpenCGChromatin, a high-performance coarse-grained model that achieves near-atomistic…
DCAF7 is one of the few DCAFs expressed in hematopoietic stem cells (HSCs). Using a conditional knockout mouse model, we discovered that the absence of DCAF7 leads to accumulation of differentiating progenitors in the bone marrow, and impairs self-renewal…
Abstract Speech processing involves a hierarchy of cognitive layers from low-level phonetic to high-level semantic representations. However, interactions are not only feed-forward; feedback mechanisms are crucial for real-time, accurate speech recognition. Yet…
Although increasing evidence implicates subchondral bone alterations in osteoarthritis, the spatial organization of subchondral bone remodeling remains unclear. Applying spatial transcriptomics to human subchondral bone, we identify a spatially conserved…
Triple-negative breast cancer (TNBC) develops in hypoxic, nutrient-limited tumors enriched with macrophages and cell death. We show that metabolically distinct TNBCs differentially exploit macrophage-derived nutrients, influencing tumor growth and therapeutic…
High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in…
Antimicrobial resistance is a major global health threat, with disproportionate impact in regions with limited diagnostic infrastructure. To address this challenge, we developed BADLOCK (Bacterial and AMR Detection by SHERLOCK), a rapid, low-cost molecular…
Immune protection against infection is often treated as a fixed property of a person’s immune response. But infection risk also depends on the number of infectious contacts a person experiences, which generally increases as community transmission rises. This…
Cerebral venous sinus thrombosis (CVST) and carotid web (CW) are distinct cerebrovascular disorders where vascular geometry, disturbed hemodynamics, and endothelial activation interact to drive thrombosis. Both conditions disproportionately affect women, yet…
Despite substantial treatment improvements, the 5-year survival rate for metastatic osteosarcoma (OS) is still as low as 20%. Immunocompetent genetic mouse models of OS have been introduced, enabling in vivo OS studies. Here, we present the ROCCIA mouse, a…
Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using…
Abstract Despite loss of responsiveness to exogenous leptin in obesity, endogenous leptin continues to restrain feeding, although the neural substrates that remain sensitive and mediate this effect remain unknown. Combining spatial transcriptomics with…
Post-transcriptional transfer RNA (tRNA) modifications dynamically regulate translational capacity, yet whether the tRNA epitranscriptome is temporally coordinated with gene expression programs during bacterial growth remains unknown. Here, we combine…
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bioRxiv and medRxiv, where new biology often lands months before the journal version. Not peer reviewed. Filtered on subject relevance rather than quality, since no quality signal exists at this stage.
Torpor is a physiological strategy used by which some species conserve energy by lowering metabolic rates and body temperatures. While mammalian hibernation is well-studied, the molecular mechanisms governing the rapid entry into avian torpor remain poorly…
Is a real object the same as its image? Vision and its neural basis have been studied almost entirely with images. However, real objects are fundamentally different, because we can act on them. But since we see and interact with real objects differently each…
Klebsiella pneumoniae (Kp) is an antibiotic-resistant pathogen that colonizes the gastrointestinal tract and can disseminate to peripheral sites, causing infections including bacteremia, urinary tract infections, and pneumonia. Intestinal Kp colonization is a…
Plant-derived flavonoids show measurable anti-dengue activity in cell culture, but their translational value is limited by a narrow therapeutic window: the concentrations that inhibit the virus approach or exceed those that are cytotoxic. Whether nanoparticle…
Primary cilium-dependent hedgehog signalling governs embryonic patterning and organ homeostasis, and its dysfunction causes ciliopathies, a clinically diverse spectrum of developmental and reproductive disorders. Whether environmental chemicals can produce…
Patients with primary immunodeficiency (PI) face prolonged diagnostic delays and may increasingly turn to large language models (LLMs) to interpret their symptoms during this period. We evaluated whether an LLM could recognize PI from symptom descriptions…
Background. Women with premature myocardial infarction (MI) have worse outcomes than similarly aged men despite less severe disease, and stress-related factors have been implicated. We examined sex differences in the association of mental stress-induced…
Glioblastoma (GBM) is increasingly recognized as a disease that perturbs and interacts with distributed brain networks, yet its imaging-based prognostic assessment remains largely focused on local tumor extent. Here, we ask whether brain-wide tumor involvement…
Genetic diagnosis requires attributing a patient's disease to variant(s). We formalize this attribution through the Probability of Necessity (PN), a counterfactual estimand modeling the probability that disease would not have occurred absent a germline variant…
Purpose: Videourodynamics (VUDS) are used to assess bladder dysfunction and risk of upper urinary tract deterioration in patients with spina bifida (SB), but interpretation is subject to interrater variability. Machine learning models have previously…
Machine learning offers a promising framework for transforming neuroimaging into predictive tools for psychiatric phenotypes. However, a major translational challenge is whether models trained on large, heterogeneous population cohorts can generalize to…
BACKGROUND Accurate differential diagnosis of complex neurological disorders remains challenging due to overlapping clinical features and heterogeneous disease presentations. Although large language models (LLMs) show promise in clinical reasoning, prior…
Irritable bowel syndrome (IBS) is a common disorder of brain-gut interaction characterized by recurrent abdominal pain and altered bowel habits. Although music-based interventions (MBIs) have shown benefits on pain and stress, the mechanisms associated with…
Introduction. Lifelong genomic medicine, in which stored genomic data informs a lifetime of care, is moving from vision toward reality, with dozens of newborn sequencing projects underway worldwide and reanalysis of data already in clinical practice.…
Chronic care requires sequential treatment under competing biomarker, safety, and cost constraints, yet clinical goal structures differ across diseases. This version asks whether one physiology-informed reinforcement-learning paradigm can be written once and…
Background The nonfluent/agrammatic (nfv) and logopenic (lv) variants of primary progressive aphasia (PPA) disrupt fluency through distinct underlying neurocognitive mechanisms. Differential diagnosis currently requires hours of cognitive-linguistic testing,…
A minority of asbestos-exposed individuals develop Pleural mesothelioma (PM), suggesting a role for inherited genetic factors. We performed germline whole-exome sequencing of blood from 127 EPIC participants who developed PM and controls. Rare…
Background: Quality Control Circle (QCC) reports are often reviewed qualitatively, but reviewer workload and inter-rater variability make large-scale assessment difficult. We evaluated whether multiple large language models (LLMs) could score QCC…
Abstract Introduction Extrapulmonary tuberculosis (EPTB) is rising in India and carries higher case fatality than pulmonary tuberculosis (PTB). A Phase III trial of VPM1002 missed its primary composite endpoint, but secondary endpoints showed a stronger EPTB…
Background: Multiple performance measures are used to assess the management of common cardiovascular conditions, such as coronary artery disease (CAD), heart failure with reduced ejection fraction (HFrEF), and atrial fibrillation (AF). These measures are…
Model averaging combines the predictions of several population pharmacokinetic models to support model-informed precision dosing, but how to select ensemble models remains unexplored. Using tacrolimus as a case study, we first evaluated all possible ensembles…
Stroboscopic light stimulation (SLS) is a candidate non-pharmacological intervention that induces transient visual and affective experiences, with potential application in depression. Before efficacy testing, clinical development requires safety, tolerability,…
Antibiotic resistance (ABR) is a global threat, yet its dynamics strongly vary across countries. Drivers of such heterogeneity remain unclear, limiting efforts to mitigate emergence and worldwide spread of multi-resistant clones. We developed a mechanistic…
Background Parkinson disease (PD) is associated with increased sedentary time and reduced cardiorespiratory fitness, making exercise an important component of disease management. Although exercise improves cardiorespiratory fitness, individuals with PD vary…
Dietary supplements are increasingly being adopted by physically active individuals to support exercise performance and recovery. This randomised, double-blind, placebo-controlled trial evaluated the ergogenic potential of SpinoleRG, an HPLC-PDA-standardised…
Background: Barretts esophagus (BE), defined by specialized intestinal metaplasia (SIM), is the recognized precursor to esophageal adenocarcinoma (EAC). Despite established screening guidelines for high-risk populations, uptake of endoscopic screening remains…
Objective: To test whether two brief mania measures, the Parent General Behavior Inventory-10 Mania form (PGBI-10M) and 7-Up, retain useful psychometric properties in a large population cohort, and to evaluate whether the PGBI-10M can identify Kiddie Schedule…
Background Loss to follow-up (LTFU) during tuberculosis treatment is a major programmatic gap, but how much excess mortality it causes has been difficult to estimate, because individuals who disengage differ from those who do not, and they must survive long…
Objective: Overweight and obesity in childhood and adolescence are major risk factors for health problems across the lifespan. This manuscript reports the current prevalence of overweight and obesity among children and adolescents aged 4-17years living in…
Background People diagnosed with severe mental illnesses (SMI) including bipolar disorder, schizophrenia and psychosis are disproportionately exposed to adverse social determinants of health, contributing to premature morbidity and mortality. Social…
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Phase 2 and 3 interventional studies from ClinicalTrials.gov. One real limit worth knowing: Indian trials mostly register with CTRI, not CT.gov. So "India" here means a global study running Indian sites, which is where large pharma touches India. Reading CTRI is the next thing to add.
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome…
In this study, researchers will learn more about omaveloxolone, also known as BIIB141 or SKYCLARYS®. Omaveloxolone is already approved for people with Friedreich's Ataxia (FA) who are 16 years of age or older. However, it is not yet…
Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with…
The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia…
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
The purpose of this study is to provide continued access to anifrolumab to eligible participants who are continuing to derive clinical benefit from treatment at the end of a parent clinical study, as assessed by the Investigator, while…
This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.
The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival…
This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal…
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy…
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is…
This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative…
Voltage Gated Sodium Channels Over the years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage gated sodium channels (VGSC) expressed in non-nervous or non-muscular organs are often…
Triple-negative breast cancer is a subtype of breast cancer that is clinically negative for expression of estrogen and progesterone receptors (ER/PR) and HER2 protein. It is characterized by its unique molecular profile, aggressive…
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they…
The overall purpose of this two-part study is to evaluate the efficacy, safety and tolerability of iptacopan (LNP023) in addition to standard of care treatment.
This study is open to adults who are at least 18 years old living with obesity and have: * a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and * moderate or advanced liver…
This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations). The purpose of this study is to find out…
This study is open to adults who are at least 18 years old and have: * A confirmed liver disease called non-alcoholic steatohepatitis (NASH) or * A confirmed liver disease called metabolic-associated steatohepatitis (MASH) * BMI of 27 kg/m2…
This study is open to adults with systemic lupus erythematosus (SLE). The purpose of this study is to find out whether a medicine called BI 3000202 helps people with SLE. The study tests different doses of BI 3000202 and aims to find the…
This study is a multicenter, randomized, double-blind, positive parallel controlled phase III clinical trial to compare efficacy, immunogenicity, pharmacokinetics, pharmacodynamics and safety of omalizumab α(CMAB007) and Xolair® in patients…
Phase 2 study to assess the efficacy of topically administered eyedrops of INV-102 during a 12-week dosing period in subjects with non-center involved DME (NCIDME) associated with NPDR \[Part 1\] and during an 8-week dosing period in…
This phase III trial compares the addition of total ablative therapy to the usual systemic therapy versus the usual systemic therapy alone in treating patients with advanced colorectal cancer that has spread to up to 4 body sites (limited…
The investigators propose to develop and test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
Background: Sjogren disease is an autoimmune disease - that is, a disease that causes the body's immune system to attack its own organs and tissues. Sjogren disease can affect the kidneys, lungs, or other organs. It can also cause dry mouth…
Background: \- Plexiform neurofibromas are tumors that grow in and around nerves. The only way to treat them is with surgery. Some of these tumors cannot be completely removed. The tumors may be too large, too numerous, or in a bad location…
The primary objective of the trial is to describe the long-term safety and tolerability of TEV-56286 administered orally for the treatment of adult participants with Multiple System Atrophy (MSA). A secondary objective of the trial is to…
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD). While current surgical therapies successfully reattach…
This research study is studying a combination of drugs as a possible treatment for breast cancer that has tested positive for a protein called HER2. The names of the study interventions involved in this study are: * Trastuzumab emtansine…
Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals. In people without alcohol use disorder (AUD), CBD has been show to be effective in…
This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG).
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab,…
The purpose of this study was to determine the antitumor activity of enfortumab vedotin (EV) confirmed by the objective response rate (ORR). This study also evaluated the effect of antibody-drug conjugate (ADC), total antibody (TAb) and…
Background: \- Many people who have traumatic brain injury (TBI) have low levels of physical fitness. Low physical fitness causes severe fatigue that reduces the ability to perform routine daily activities, and may also cause increased…
The study, led by Zhejiang Cancer Hospital and sponsored by Bio-Thera Solutions, Ltd., is an exploratory multicenter, open-label phase Ib-II clinical trial evaluating the safety, tolerability, pharmacokinetic characteristics, and…
This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal…
Background: Shingles is a painful, blistering rash caused by the same virus that causes chickenpox. Shingrix is a vaccine approved to prevent shingles in healthy adults over age 50 and in immunocompromised adults over age 18. Researchers…
The main purpose of this trial is to find out whether BHB-1893 works better than metoprolol in adults with symptoms of obstructive hypertrophic cardiomyopathy (oHCM). The trial includes adults who are currently being treated for oHCM or who…
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III study with an open-label extension. The purpose is to evaluate efficacy and safety in adult patients with chronic hepatitis B virus infection who have received at…
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Rounds, approvals, launches and company moves from 13 trade and business feeds. Specialist bioscience outlets pass through. General business feeds have to earn their place on a keyword in the headline.
Motilal Oswal Alternates has sold a little over 2 per cent stake in Molbio Diagnostics for ₹306 crore through open market transactions on Wednesday. Business Excellence Trust III, a fund of Motilal Oswal Alternates,…
Delhi NCR-based NBFC Seeds Fincap raised more than ₹100 Cr ($10.4 Mn) in a Series B funding round led by…
The manufacturing facility adds 135 million-unit annual capacity, with Carbapenem line now operational and validated under Biodeal’s ownership The post Biodeal Pharmaceuticals acquires Biological E facility, expands into…
India’s CRDMO sector is gaining importance as global pharma seeks resilient, cost-efficient supply chains. Akhil Ravi, CEO, Aurigene Pharmaceutical Services, discusses the company’s capabilities across small molecules,…
Aesthetic treatments were generally used for correction purposes until recently. The usual practice was to smooth out wrinkles, lessen pigmentation, resurface scars, and treat hair loss. All these things have changed as…
Plans 12 new actives, including five biologicals, for launch over next decade
The state fire and emergency services department has expanded its ongoing fire-safety audit drive to hospitals. Teams from the department inspected several private healthcare establishments across south Calcutta on…
Fixderma has grown from its 2010 launch into a company exporting to over 35 countries with a 130-plus product portfolio. Looking back, which single decision or pivot do you think had the biggest impact on that…
Wall Street has poured about $10 billion into Indian hospital chains over the past five years, with investors including Blackstone, KKR, TPG and General Atlantic betting on India’s huge shortage of hospital beds and…
This drop has come despite the fact that more number of farmers had purchased the fertilisers in Kharif 2026 than year-ago in these districts where pilot was implemented
The Indian Council of Medical Research (ICMR) has invited proposals to establish Centres for Advanced Research (CARs) focused on developing priority medical devices and diagnostic technologies. The centres will work on…
United Private Hospitals and Diagnostic Association (UPHDA) will boycott MP Ayushman Bharat Niramayam (MP-ABN) from Oct 8 in Madhya Pradesh over mandatory provision of National Accreditation Board for Hospitals &…
The MRP (maximum retail price) of 36 medicines examined at hospital pharmacies across Uttar Pradesh was found to be more than 10 times their procurement price, with the gap reaching nearly 67 times in one case. The…
House of Diagnostics (HOD) has appointed Dr Raj Prabha Patra as Chief Operating Officer (COO), strengthening its leadership team as the integrated diagnostics provider focuses on operational excellence and growth. In her…
Congress group leader in the BMC Ashraf Azmi has questioned the proposed cancellation of procurement of two Endoscopic Ultrasound (EUS) machines for KEM Hospital and LTMG Hospital, arguing that the move could further…
Hospital stocks remained under pressure for a second straight session on Thursday as investors continued to assess the potential impact of tighter regulation of medicine mark-ups at private hospitals following the…
The amount received by government hospitals for treating patients under the Ayushman Bharat and Chirayu schemes would be utilised for providing special incentives to doctors and staff at the respective hospitals,…
Chandan Healthcare Limited has acquired two diagnostic units of Ansh Diagnostics & Health Care located in Gyan Khand II and Ahinsa Khand I, Indirapuram, Ghaziabad. Ansh Diagnostics & Health Care is an established…
The study is significant because endometriosis often takes 3 to 7 years to diagnose, even though it can cause severe menstrual pain, pain during intercourse, infertility and, in advanced cases, complications involving…
Delhi NCR has 39 hospitals with robotic systems, while 11 hospitals have more than one such system, making the region the country's leading hub for robotic-system installations, according to data presented at the…
The arrangement would require even those with comprehensive health insurance to keep funds for medical emergencies, as they would have to pay 10% of admissible inpatient hospitalisation costs, including those arising…
The latest increase in wheat MSP amounts to just 25 paise per kg, SKM said and questions the government's claim that the new MSPs provide a 106% return over the cost of production
From K-pop to AI, Karnataka is looking to turn India’s growing Korean connection into investment and technology partnerships.
Addressing the inaugural session of the International Conference of the Society of Robotic Surgery, Singh said robotics, along with AI and nanoscience, would create a larger ecosystem for precision health delivery and…
Noida-based Yatharth Hospital and Trauma Care Services operates a network of super-speciality hospitals in India, providing comprehensive healthcare services, diagnostics, and advanced medical procedures across multiple…
When Xaira Therapeutics first debuted in 2024 with a gobsmacking $1 billion in funding, a natural expectation would have been for a flurry of further activity to follow. Instead, the buzzy AI biotech went quiet.
Novartis is paying Abogen Biosciences $575 million upfront for an mRNA-encoded T-cell engager that showed early clinical promise in autoimmune disease. The deal, which includes up to $7.2 billion in milestones, comes…
Merck & Co. touted a win for its anti-TL1A antibody in a phase 2b trial in patients with moderate to severe hidradenitis suppurativa (HS).
The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.
Unlike other therapies in this class, Abogen’s ABO2203 is designed to produce a T-cell engager protein in vivo through an mRNA-encoded system.
Varda secures this capital as drugmakers tout the potential of manufacturing in microgravity conditions to create differentiated medicines.
Why Your Operating Model Should Reflect Your Company’s DNA
Eric Cantor, who represented Virginia in the U.S. House of Representatives for 14 years and served as House majority leader from 2011 to 2014, will step up as PhRMA’s next president and CEO on Nov. 9. Plus, Bayer has a…
Adecto Pharmaceuticals’ 12-year story has come to an end as the immunotherapy biotech blamed a “risk-averse funding environment” for shutting up shop.
Abbott is kick-starting the U.S. commercial launch of SimpleScreen CRC, an FDA-approved blood-based colorectal cancer (CRC) screening test for adults age 45 and older who are at average risk for the disease.
As always, if you know of layoffs occurring at a biotech, please reach out to the Fierce Biotech editorial team.
The revelation of a patient death in Bristol Myers Squibb’s phase 3 trial of a potential pulmonary fibrosis treatment has raised concerns ahead of the study’s readout, but analysts were quick to dispel worries about…
Roche Diagnostics has launched a new in vitro diagnostic test for newborn screening to detect a series of rare disorders.
A more subdued volume of biopharma layoffs continued into the third quarter of 2026, validating predictions that the sector has moved beyond the avalanche of redundancies experienced last year.
Foghorn Therapeutics is laying off 40% of its workforce after a long-running collaboration with Eli Lilly collapsed over disappointing phase 1 data.
When recombinant DNA pioneer Herbert Boyer, Ph.D., first got a call from venture capitalist Robert Swanson about starting a company, the savvy scientist wasn’t sure a meeting would be worth his time.
A phase 3 trial of Boehringer Ingelheim’s survodutide in people with obesity and Type 2 diabetes has met its co-primary endpoints. Yet, with the readout echoing earlier data that underwhelmed analysts, shares in…
Sanofi is paying Regeneron $1 billion upfront to collaborate on four early-stage immunology programs, teeing the longstanding partners up to try to replicate Dupixent’s success.
Eli Lilly announced its amylin-Zepbound combination eloraTZP resulted in 23.3% weight loss in adults with type 2 diabetes and obesity or overweight, topping its own triple-G drug candidate retatrutide in that population.
Base editing biotech Beam Therapeutics is suing one of its newest rivals, alleging that the upstart company stole the secrets behind one of its lead programs and used them to craft a competing therapy.
GSK is paying Wave Life Sciences $12 million upfront to take ownership of a hepatic program arising from the companies’ long-running collaboration.
Highlight Therapeutics touted positive topline results in patients with localized high-risk head and neck basal cell carcinoma (BCC).
Connect Biopharma has pointed to phase 2 data for its IL-4/IL-13 blocker as proof that the wannabe Dupixent rival can reduce respiratory attacks—although the study missed a secondary endpoint tied to a breathing test.
The FDA has granted 510(k) clearance to Miami-based VertigoDx for its portable diagnostic system that can evaluate vertigo, including benign paroxysmal positional vertigo (BPVV).
Zealand Pharma has shared primary endpoint data on Roche-partnered petrelintide, revealing that the middle dose of the amylin analog delivered the highest weight loss—9.8%—at Week 28.
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